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Gar1 GAR1 ribonucleoprotein [ Mus musculus (house mouse) ]

Gene ID: 68147, updated on 2-Nov-2024

Summary

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Official Symbol
Gar1provided by MGI
Official Full Name
GAR1 ribonucleoproteinprovided by MGI
Primary source
MGI:MGI:1930948
See related
Ensembl:ENSMUSG00000028010 AllianceGenome:MGI:1930948
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nola1; C430047J18Rik
Summary
Predicted to enable box H/ACA snoRNA binding activity and telomerase RNA binding activity. Predicted to be involved in snoRNA guided rRNA pseudouridine synthesis and telomere maintenance via telomerase. Predicted to be located in dense fibrillar component; fibrillar center; and nucleoplasm. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Predicted to colocalize with chromosome, telomeric region. Orthologous to human GAR1 (GAR1 ribonucleoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver E14 (RPKM 26.6), CNS E11.5 (RPKM 25.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Gar1 in Genome Data Viewer
Location:
3 G3; 3 59.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (129618561..129625045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (129824912..129831407, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene predicted gene, 36130 Neighboring gene retinal pigment epithelium derived rhodopsin homolog Neighboring gene STARR-positive B cell enhancer ABC_E7942 Neighboring gene predicted gene, 36180 Neighboring gene complement component factor i Neighboring gene phospholipase A2, group XIIA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. Pogacić V, et al. Mol Cell Biol, 2000 Dec. PMID 11074001, Free PMC Article
  2. Specificity and stoichiometry of subunit interactions in the human telomerase holoenzyme assembled in vivo. Egan ED, et al. Mol Cell Biol, 2010 Jun. PMID 20351177, Free PMC Article
  3. HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment. Kappei D, et al. EMBO J, 2013 Jun 12. PMID 23685356, Free PMC Article
  4. Beads-free protein immunoprecipitation for a mass spectrometry-based interactome and posttranslational modifications analysis. Mikula M, et al. Proteome Sci, 2015. PMID 26336360, Free PMC Article
  5. Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation. Cidad P, et al. J Cell Physiol, 2021 Jun. PMID 33230847

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables box H/ACA snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables box H/ACA snoRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables box H/ACA snoRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snoRNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables telomerase RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables telomerase RNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in pseudouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snoRNA guided rRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snoRNA guided rRNA pseudouridine synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in telomere maintenance via telomerase ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in telomere maintenance via telomerase NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
part_of box H/ACA snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box H/ACA snoRNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of box H/ACA snoRNP complex ISO
Inferred from Sequence Orthology
more info
  
part_of box H/ACA telomerase RNP complex IEA
Inferred from Electronic Annotation
more info
  
part_of box H/ACA telomerase RNP complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in dense fibrillar component ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of telomerase holoenzyme complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of telomerase holoenzyme complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
H/ACA ribonucleoprotein complex subunit 1
Names
GAR1 ribonucleoprotein homolog
H/ACA small nucleolar RNPs
nucleolar protein family A member 1
nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)
snoRNP protein GAR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429088.1 → NP_001416017.1  H/ACA ribonucleoprotein complex subunit 1

    Status: VALIDATED

    Source sequence(s)
    AC111097
    UniProtKB/Swiss-Prot
    Q80X93, Q8C6C5, Q8VDH0, Q9CY66

  2. NM_026578.4 → NP_080854.1  H/ACA ribonucleoprotein complex subunit 1

    See identical proteins and their annotated locations for NP_080854.1

    Status: VALIDATED

    Source sequence(s)
    AC111097
    Consensus CDS
    CCDS38634.1
    UniProtKB/Swiss-Prot
    Q80X93, Q8C6C5, Q8VDH0, Q9CY66
    UniProtKB/TrEMBL
    Q3TKG5
    Related
    ENSMUSP00000029643.9, ENSMUST00000029643.15
    Conserved Domains (1) summary
    pfam04410
    Location:72 → 170
    Gar1; Gar1/Naf1 RNA binding region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    129618561..129625045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240208.4 → XP_011238510.1  H/ACA ribonucleoprotein complex subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam04410
    Location:72 → 170
    Gar1; Gar1/Naf1 RNA binding region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CY66.1 GenPept UniProtKB/Swiss-Prot:Q9CY66

Gene LinkOut

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