U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Arl13b ADP-ribosylation factor-like 13B [ Mus musculus (house mouse) ]

Gene ID: 68146, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Arl13bprovided by MGI
Official Full Name
ADP-ribosylation factor-like 13Bprovided by MGI
Primary source
MGI:MGI:1915396
See related
Ensembl:ENSMUSG00000022911 AllianceGenome:MGI:1915396
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hnn; Arl2l1; A530097K21Rik; A930014M17Rik; C530009C10Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Involved in nervous system development; non-motile cilium assembly; and smoothened signaling pathway. Acts upstream of or within dorsal/ventral pattern formation; heart looping; and left/right axis specification. Located in axoneme; ciliary membrane; and motile cilium. Is expressed in several structures, including chordamesoderm; embryo mesenchyme; gonad; neural ectoderm; and node. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Orthologous to human ARL13B (ADP ribosylation factor like GTPase 13B). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.6), testis adult (RPKM 3.9) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Arl13b in Genome Data Viewer
Location:
16 C1.3; 16 36.43 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (62613671..62667418, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (62793308..62847055, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41128 Neighboring gene NOL1/NOP2/Sun domain family member 3 Neighboring gene predicted gene, 52231 Neighboring gene STARR-positive B cell enhancer ABC_E7471 Neighboring gene syntaxin 19 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:62846895-62847078 Neighboring gene STARR-seq mESC enhancer starr_41130 Neighboring gene STARR-seq mESC enhancer starr_41131 Neighboring gene protein S (alpha) Neighboring gene STARR-positive B cell enhancer mm9_chr16:62940376-62940676 Neighboring gene STARR-seq mESC enhancer starr_41132 Neighboring gene predicted gene, 53931

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse. Van Sciver RE, et al. Dev Biol, 2023 Aug. PMID 37209936, Free PMC Article
  2. Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts. Lin T, et al. Tissue Cell, 2023 Jun. PMID 37058812
  3. The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons. Habif JC, et al. Development, 2023 Jan 15. PMID 36661357, Free PMC Article
  4. ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling. Chen L, et al. Neuro Oncol, 2023 May 4. PMID 36322624, Free PMC Article
  5. The ciliary GTPase Arl13b regulates cell migration and cell cycle progression. Pruski M, et al. Cell Adh Migr, 2016 Jul 3. PMID 26963749, Free PMC Article

See all (246) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
    Title: Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain.
  2. Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts.
    Title: Arl13b promotes the proliferation, migration, osteogenesis, and mechanosensation of osteoblasts.
  3. Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse.
    Title: Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse.
  4. ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling.
    Title: ARL13B promotes angiogenesis and glioma growth by activating VEGFA-VEGFR2 signaling.
  5. The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons.
    Title: The role of a ciliary GTPase in the regulation of neuronal maturation of olfactory sensory neurons.
  6. Arl13b controls basal cell stemness properties and Hedgehog signaling in the mouse epididymis.
    Title: Arl13b controls basal cell stemness properties and Hedgehog signaling in the mouse epididymis.
  7. Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting.
    Title: Smoothened and ARL13B are critical in mouse for superior cerebellar peduncle targeting.
  8. The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.
    Title: The Ciliary Protein Arl13b Functions Outside of the Primary Cilium in Shh-Mediated Axon Guidance.
  9. Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.
    Title: Ahi1 promotes Arl13b ciliary recruitment, regulates Arl13b stability and is required for normal cell migration.
  10. ARL13B is required at multiple stages of retinogenesis, including early postnatal proliferation of retinal progenitor cells, development of photoreceptor cilia, and morphogenesis of photoreceptor OS discs regardless of sex. ARL13B is needed for photoreceptor maintenance and protein trafficking. trafficking.
    Title: ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in formation of radial glial scaffolds IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in interneuron migration from the subpallium to the cortex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within left/right axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neural tube patterning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in receptor localization to non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cilium TAS
Traceable Author Statement
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
is_active_in motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in non-motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ADP-ribosylation factor-like protein 13B
Names
ADP-ribosylation factor-like 2-like 1
ARL2-like protein 1
protein hennin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026577.4 → NP_080853.3  ADP-ribosylation factor-like protein 13B

    See identical proteins and their annotated locations for NP_080853.3

    Status: VALIDATED

    Source sequence(s)
    AC154309, AK016794, AK021270, CF741686
    Consensus CDS
    CCDS28261.1
    UniProtKB/Swiss-Prot
    G3X9K5, Q640N2
    Related
    ENSMUSP00000086703.6, ENSMUST00000089289.6
    Conserved Domains (2) summary
    cd04161
    Location:23 → 189
    Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
    pfam00071
    Location:24 → 172
    Ras; Ras family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    62613671..62667418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522504.4 → XP_006522567.1  ADP-ribosylation factor-like protein 13B isoform X2

    Conserved Domains (1) summary
    cl38936
    Location:1 → 86
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006522505.5 → XP_006522568.1  ADP-ribosylation factor-like protein 13B isoform X3

    Conserved Domains (1) summary
    cl38936
    Location:21 → 82
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_006522503.5 → XP_006522566.1  ADP-ribosylation factor-like protein 13B isoform X1

    Conserved Domains (1) summary
    cd04161
    Location:23 → 189
    Arl2l1_Arl13_like; Arl2-like protein 1 (Arl2l1) and Arl13
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q640N2.2 GenPept UniProtKB/Swiss-Prot:Q640N2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous