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Tpk1 thiamin pyrophosphokinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 680668, updated on 2-Nov-2024

Summary

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Official Symbol
Tpk1provided by RGD
Official Full Name
thiamin pyrophosphokinase 1provided by RGD
Primary source
RGD:1589408
See related
EnsemblRapid:ENSRNOG00000029922 AllianceGenome:RGD:1589408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable UTP thiamine diphosphokinase activity; identical protein binding activity; and thiamine diphosphokinase activity. Predicted to be involved in regulation of acetyl-CoA biosynthetic process from pyruvate and thiamine diphosphate biosynthetic process. Predicted to act upstream of or within thiamine metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in inherited metabolic disorder. Orthologous to human TPK1 (thiamin pyrophosphokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 56.0), Liver (RPKM 31.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tpk1 in Genome Data Viewer
Location:
4q24
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (73170125..73557683, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (72170134..72557707, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (72792252..73174179, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548553 Neighboring gene Rho guanine nucleotide exchange factor 5 Neighboring gene uncharacterized LOC108350700 Neighboring gene NOBOX oogenesis homeobox Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486575

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. Nosaka K, et al. J Biol Chem, 1999 Nov 26. PMID 10567383
  2. A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. Wei X, et al. PLoS Genet, 2014 Dec. PMID 25502805, Free PMC Article
  3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
  4. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC188595

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables UTP thiamine diphosphokinase activity IEA
Inferred from Electronic Annotation
more info
  
enables UTP thiamine diphosphokinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiamine binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine diphosphokinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within thiamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thiamin pyrophosphokinase 1
Names
thiamine pyrophosphokinase
NP_001128466.1
XP_038964271.1
XP_038964272.1
XP_063142747.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134994.1 → NP_001128466.1  thiamin pyrophosphokinase 1

    See identical proteins and their annotated locations for NP_001128466.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    A0A8I6A5F8, A0A9K3Y7A3, B5DEJ6, F1LQE3
    Related
    ENSRNOP00000044768.4, ENSRNOT00000048203.6
    Conserved Domains (2) summary
    cd07995
    Location:20 → 239
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21 → 241
    PLN02714; thiamin pyrophosphokinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    73170125..73557683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286677.1 → XP_063142747.1  thiamin pyrophosphokinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZSI7, A6IFA7
    Related
    ENSRNOP00000081223.1, ENSRNOT00000107440.2

  2. XM_039108343.2 → XP_038964271.1  thiamin pyrophosphokinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A5F8
    Related
    ENSRNOP00000086227.2, ENSRNOT00000102331.2
    Conserved Domains (1) summary
    PLN02714
    Location:5 → 217
    PLN02714; thiamin pyrophosphokinase

  3. XM_039108344.2 → XP_038964272.1  thiamin pyrophosphokinase 1 isoform X2

    Conserved Domains (1) summary
    PLN02714
    Location:21 → 205
    PLN02714; thiamin pyrophosphokinase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials