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Nutf2 nuclear transport factor 2 [ Mus musculus (house mouse) ]

Gene ID: 68051, updated on 2-Nov-2024

Summary

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Official Symbol
Nutf2provided by MGI
Official Full Name
nuclear transport factor 2provided by MGI
Primary source
MGI:MGI:1915301
See related
Ensembl:ENSMUSG00000008450 AllianceGenome:MGI:1915301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ntf2; Ntf3; PP15; 2700067I02Rik
Summary
Predicted to enable identical protein binding activity; nuclear import signal receptor activity; and small GTPase binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytosol; nuclear outer membrane; and nucleoplasm. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including alimentary system; central nervous system; integumental system; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 42.8), CNS E14 (RPKM 34.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Nutf2 in Genome Data Viewer
Location:
8 D3; 8 53.05 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106587165..106607034)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105860533..105880402)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene centromere protein T Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene THAP domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An ATP-dependent activity that releases RanGDP from NTF2. Yamada M, et al. J Biol Chem, 2004 Aug 27. PMID 15155737
  2. Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. Bayliss R, et al. J Mol Biol, 1999 Oct 29. PMID 10543952
  3. Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. Sakakida Y, et al. J Biol Chem, 2005 Apr 8. PMID 15689618
  4. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102015

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear import signal receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables nucleocytoplasmic carrier activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of vascular endothelial growth factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nuclear pore ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nuclear pore ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore central transport channel ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
nuclear transport factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357229.1 → NP_001344158.1  nuclear transport factor 2

    Status: VALIDATED

    Source sequence(s)
    AC116569, AC159265
    Consensus CDS
    CCDS22617.1
    UniProtKB/Swiss-Prot
    P61971, Q3TI35
    UniProtKB/TrEMBL
    Q3U8H8
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  2. NM_001357230.1 → NP_001344159.1  nuclear transport factor 2

    Status: VALIDATED

    Source sequence(s)
    AC116569, AC159265
    Consensus CDS
    CCDS22617.1
    UniProtKB/Swiss-Prot
    P61971, Q3TI35
    UniProtKB/TrEMBL
    Q3U8H8
    Related
    ENSMUSP00000148713.2, ENSMUST00000212042.2
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

  3. NM_026532.4 → NP_080808.1  nuclear transport factor 2

    See identical proteins and their annotated locations for NP_080808.1

    Status: VALIDATED

    Source sequence(s)
    AK002461, BC086773, CJ059612
    Consensus CDS
    CCDS22617.1
    UniProtKB/Swiss-Prot
    P61971, Q3TI35
    UniProtKB/TrEMBL
    Q3U8H8
    Related
    ENSMUSP00000008594.8, ENSMUST00000008594.9
    Conserved Domains (1) summary
    cd00780
    Location:7 → 122
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106587165..106607034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61971.1 GenPept UniProtKB/Swiss-Prot:P61971

Gene LinkOut

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