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Gnb1l G protein subunit beta 1 like [ Rattus norvegicus (Norway rat) ]

Gene ID: 680266, updated on 2-Nov-2024

Summary

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Official Symbol
Gnb1lprovided by RGD
Official Full Name
G protein subunit beta 1 likeprovided by RGD
Primary source
RGD:1594165
See related
EnsemblRapid:ENSRNOG00000001891 AllianceGenome:RGD:1594165
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in DNA damage checkpoint signaling. Predicted to act upstream of or within social behavior. Predicted to be located in cytoplasm and nucleus. Orthologous to human GNB1L (G protein subunit beta 1 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 12.7), Thymus (RPKM 10.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gnb1l in Genome Data Viewer
Location:
11q23
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95933994..96011933, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82425301..82507836, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86575229..86655614, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481101 Neighboring gene T-box transcription factor 1 Neighboring gene uncharacterized LOC120095703 Neighboring gene thioredoxin reductase 2 Neighboring gene catechol-O-methyltransferase Neighboring gene ARVCF, delta catenin family member Neighboring gene small Cajal body-specific RNA 14 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Paylor R, et al. Proc Natl Acad Sci U S A, 2006 May 16. PMID 16684884, Free PMC Article
  2. Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes. Maynard TM, et al. Mol Cell Neurosci, 2008 Nov. PMID 18775783, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within social behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein subunit beta-like protein 1
Names
guanine nucleotide binding protein (G protein), beta polypeptide 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398877.1 → NP_001385806.1  guanine nucleotide-binding protein subunit beta-like protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/TrEMBL
    D4A2F0, M0R4I1
    Related
    ENSRNOP00000064268.2, ENSRNOT00000073377.4
    Conserved Domains (2) summary
    sd00039
    Location:24 → 64
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:12 → 321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    95933994..96011933 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248654.5 → XP_006248716.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X3

    See identical proteins and their annotated locations for XP_006248716.1

    Conserved Domains (3) summary
    COG2319
    Location:14 → 289
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:23 → 64
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:12 → 288
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_039088981.2 → XP_038944909.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X1

    UniProtKB/TrEMBL
    D4A2F0, M0R4I1
    Conserved Domains (2) summary
    sd00039
    Location:24 → 64
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:12 → 321
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_017598200.2 → XP_017453689.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X2

    Related
    ENSRNOP00000102738.1, ENSRNOT00000141470.1

  4. XM_039088982.1 → XP_038944910.1  guanine nucleotide-binding protein subunit beta-like protein 1 isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:108 → 147
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:71 → 219
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_005491494.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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