STRN striatin [Homo sapiens (human)] - Gene

Summary

Official Symbol: STRNprovided by HGNC
Official Full Name: striatinprovided by HGNC
Primary source: HGNC:HGNC:11424
See related: Ensembl:ENSG00000115808 MIM:614765; AllianceGenome:HGNC:11424
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SG2NA; STRN1; PPP2R6A
Summary: Enables armadillo repeat domain binding activity; estrogen receptor binding activity; and protein phosphatase 2A binding activity. Involved in Wnt signaling pathway and negative regulation of cell population proliferation. Located in bicellular tight junction. Part of FAR/SIN/STRIPAK complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in esophagus (RPKM 6.7), brain (RPKM 5.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2p22.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (36837698..36966536, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (36844882..36973674, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (37064841..37193679, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Striatin Gene Variants Are Associated With Salt Sensitivity of Blood Pressure by Mechanisms That Differ in Women and Men.
Title: Striatin Gene Variants Are Associated With Salt Sensitivity of Blood Pressure by Mechanisms That Differ in Women and Men.
Placental expression of striatin & endothelial nitric oxide synthase in women with & without pre-eclampsia.
Title: Placental expression of striatin & endothelial nitric oxide synthase in women with & without pre-eclampsia.
Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.
Title: Phosphorylation of Influenza A Virus Matrix Protein 1 at Threonine 108 Controls Its Multimerization State and Functional Association with the STRIPAK Complex.
ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy.
Title: ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy.
Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.
Title: Striatin genotype-based, mineralocorticoid receptor antagonist-driven clinical trial: study rationale and design.
we detected novel and related STRN-NTRK3 and STRN3-NTRK3 fusions in 2 fibrosarcomas that occurred in the bone and soft tissue of young adult patients
Title: Novel NTRK3 Fusions in Fibrosarcomas of Adults.
STRN-ALK gene fusion is associated with radiation-associated Thyroid Cancer.
Title: Investigation of the Relationship Between Radiation Dose and Gene Mutations and Fusions in Post-Chernobyl Thyroid Cancer.
E2 enhanced HUVEC migration, which was inhibited by silencing striatin. In conclusion, our results demonstrated that E2-mediated upregulation of striatin promotes cell migration in HUVECs.
Title: 17β-estradiol upregulates striatin protein levels via Akt pathway in human umbilical vein endothelial cells.
striatin-associated Salt Sensitive Blood Pressure is associated with normal plasma renin activity and reduced epinephrine levels
Title: Striatin Gene Polymorphic Variants Are Associated With Salt Sensitive Blood Pressure in Normotensives and Hypertensives.
The prevalence of STRN-ALK kinase fusions were determined in papillary thyroid cancer of an adult population
Title: ETV6-NTRK3 and STRN-ALK kinase fusions are recurrent events in papillary thyroid cancer of adult population.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45772 (e-PCR)
- UniSTS:47379

D2S1654E (e-PCR)
- UniSTS:25172

D2S2186 (e-PCR), detects polymorphism
- UniSTS:47963

A006J38 (e-PCR)
- UniSTS:39279

D2S2135 (e-PCR)
- UniSTS:154233

A004G18 (e-PCR)
- UniSTS:73113

STRN_8656 (e-PCR)
- UniSTS:467921

RH69347 (e-PCR)
- UniSTS:76757

G32364 (e-PCR)
- UniSTS:116954

G16360 (e-PCR)
- UniSTS:51420

RH69885 (e-PCR)
- UniSTS:75745

SHGC-36905 (e-PCR)
- UniSTS:17395

G60201 (e-PCR)
- UniSTS:137460

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IBA Inferred from Biological aspect of Ancestor more info
enables armadillo repeat domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	NAS Non-traceable Author Statement more info	PubMed
enables nuclear estrogen receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bicellular tight junction assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in dendrite development	ISS Inferred from Sequence or Structural Similarity more info
involved_in locomotory behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: striatin

Names: protein phosphatase 2 regulatory subunit B'''alpha; striatin, calmodulin binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003162.4 → NP_003153.2 striatin

See identical proteins and their annotated locations for NP_003153.2

Status: VALIDATED

Source sequence(s)

AC007382, AC007404, AJ223814, AK026934

Consensus CDS

CCDS1784.1

UniProtKB/Swiss-Prot

O43815, Q3KP65, Q53TQ8, Q9NP38

UniProtKB/TrEMBL

Q3B874

Related

ENSP00000263918.4, ENST00000263918.9

Conserved Domains (4) summary

COG2319
Location:429 → 773

WD40; WD40 repeat [General function prediction only]

cd00200
Location:455 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:48 → 173

Striatin; Striatin family

sd00039
Location:468 → 514

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

36837698..36966536 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005264519.6 → XP_005264576.1 striatin isoform X2

UniProtKB/TrEMBL

Q3B874

Conserved Domains (4) summary

COG2319
Location:392 → 736

WD40; WD40 repeat [General function prediction only]

cd00200
Location:418 → 742

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:48 → 173

Striatin; Striatin family

sd00039
Location:431 → 477

7WD40; WD40 repeat [structural motif]
XM_011533073.3 → XP_011531375.1 striatin isoform X1

UniProtKB/TrEMBL

Q3B874

Conserved Domains (4) summary

COG2319
Location:458 → 802

WD40; WD40 repeat [General function prediction only]

cd00200
Location:484 → 808

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:48 → 173

Striatin; Striatin family

sd00039
Location:497 → 543

7WD40; WD40 repeat [structural motif]