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Ddx59 DEAD box helicase 59 [ Mus musculus (house mouse) ]

Gene ID: 67997, updated on 2-Nov-2024

Summary

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Official Symbol
Ddx59provided by MGI
Official Full Name
DEAD box helicase 59provided by MGI
Primary source
MGI:MGI:1915247
See related
Ensembl:ENSMUSG00000026404 AllianceGenome:MGI:1915247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1210002B07Rik; 4833411G06Rik
Summary
Predicted to enable RNA helicase activity and mRNA binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; eye; face; lip; and oocyte. Human ortholog(s) of this gene implicated in orofaciodigital syndrome V. Orthologous to human DDX59 (DEAD-box helicase 59). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 2.8), CNS E14 (RPKM 2.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx59 in Genome Data Viewer
Location:
1 E4; 1 59.73 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136343009..136384019)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136415271..136456192)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene calmodulin regulated spectrin-associated protein family, member 2 Neighboring gene G protein-coupled receptor 25 Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene STARR-seq mESC enhancer starr_02406 Neighboring gene STARR-positive B cell enhancer ABC_E993 Neighboring gene kinesin family member 14 Neighboring gene predicted gene 29485 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138447476-138447776 Neighboring gene STARR-seq mESC enhancer starr_02411 Neighboring gene STARR-seq mESC enhancer starr_02413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:138476081-138476290 Neighboring gene STARR-positive B cell enhancer ABC_E145 Neighboring gene STARR-seq mESC enhancer starr_02418 Neighboring gene STARR-positive B cell enhancer ABC_E5807 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138521286-138521587 Neighboring gene zinc finger protein 281

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome. Shamseldin HE, et al. Am J Hum Genet, 2013 Sep 5. PMID 23972372, Free PMC Article
  2. Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. Quina LA, et al. J Neurosci, 2009 Nov 11. PMID 19906978, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data strongly implicate DDX59 RNA helicase family member in the pathogenesis of orofaciodigital syndrome.
    Title: Mutations in DDX59 implicate RNA helicase in the pathogenesis of orofaciodigital syndrome.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX59
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 59
DEAD box protein 59
zinc finger HIT domain-containing protein 5
NP_080776.1
XP_006529905.1
XP_006529906.1
XP_006529907.1
XP_036009140.1
XP_036009142.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026500.3 → NP_080776.1  probable ATP-dependent RNA helicase DDX59

    See identical proteins and their annotated locations for NP_080776.1

    Status: VALIDATED

    Source sequence(s)
    AK004833, AK133731
    Consensus CDS
    CCDS15326.1
    UniProtKB/Swiss-Prot
    Q8C667, Q9CSD1, Q9DBN9
    Related
    ENSMUSP00000027655.7, ENSMUST00000027655.8
    Conserved Domains (1) summary
    PLN00206
    Location:70 → 593
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136343009..136384019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153247.1 → XP_036009140.1  probable ATP-dependent RNA helicase DDX59 isoform X1

    Conserved Domains (1) summary
    PLN00206
    Location:70 → 563
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

  2. XM_006529844.5 → XP_006529907.1  probable ATP-dependent RNA helicase DDX59 isoform X4

    Conserved Domains (1) summary
    PLN00206
    Location:70 → 532
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

  3. XM_006529842.5 → XP_006529905.1  probable ATP-dependent RNA helicase DDX59 isoform X2

    Conserved Domains (1) summary
    PLN00206
    Location:70 → 532
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

  4. XM_006529843.4 → XP_006529906.1  probable ATP-dependent RNA helicase DDX59 isoform X3

    Conserved Domains (1) summary
    PLN00206
    Location:70 → 550
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

  5. XM_036153249.1 → XP_036009142.1  probable ATP-dependent RNA helicase DDX59 isoform X5

    Conserved Domains (1) summary
    PLN00206
    Location:70 → 520
    PLN00206; DEAD-box ATP-dependent RNA helicase; Provisional

RNA

  1. XR_004934150.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_178052.3: Suppressed sequence

    Description
    NM_178052.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DBN9.1 GenPept UniProtKB/Swiss-Prot:Q9DBN9

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