Cntln centlein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cntlnprovided by RGD
Official Full Name: centleinprovided by RGD
Primary source: RGD:1308101
See related: EnsemblRapid:ENSRNOG00000043151 AllianceGenome:RGD:1308101
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1308101
Summary: Predicted to enable protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Predicted to be involved in centriole-centriole cohesion and protein localization to organelle. Predicted to act upstream of or within several processes, including regulation of protein localization; single fertilization; and spermatogenesis. Predicted to be located in cytosol; microtubule organizing center; and nucleoplasm. Predicted to be active in sperm head-tail coupling apparatus. Orthologous to human CNTLN (centlein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 68.4), Testes (RPKM 54.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q31

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (104340801..104622491)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (99295865..99576402)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (103251986..103367088)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The molecular characterization of a novel protein, named centlein (centrosomal protein), is described. Centlein was a protein of 721 amino acids with a calculated molecular weight of 82,717 and possessed coiled-coil domains.[Centlein]
Title: Identification and characterization of the novel centrosomal protein centlein.

Submit: New GeneRIF Correction

General gene information

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Markers

BF401796 (e-PCR)
- UniSTS:245541

D5Rat196 (e-PCR), detects polymorphism
- UniSTS:227896

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in centriole-centriole cohesion	IEA Inferred from Electronic Annotation more info
involved_in centriole-centriole cohesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to organelle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in single fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in sperm head-tail coupling apparatus	IEA Inferred from Electronic Annotation more info
is_active_in sperm head-tail coupling apparatus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centlein

Names: centlein, centrosomal protein; centrosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114402.1 → NP_001107874.1 centlein

Status: VALIDATED

Source sequence(s)

AB369315, BF394214, BU759324, CB699924, JAXUCZ010000005

UniProtKB/Swiss-Prot

A9ZSY0

UniProtKB/TrEMBL

A0A8I6ASB3

Conserved Domains (1) summary

TIGR02168
Location:346 → 622

SMC_prok_B; chromosome segregation protein SMC, common bacterial type