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Tmem59l transmembrane protein 59-like [ Mus musculus (house mouse) ]

Gene ID: 67937, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem59lprovided by MGI
Official Full Name
transmembrane protein 59-likeprovided by MGI
Primary source
MGI:MGI:1915187
See related
Ensembl:ENSMUSG00000035964 AllianceGenome:MGI:1915187
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5330410G16Rik
Summary
Involved in branching involved in ureteric bud morphogenesis. Predicted to be located in Golgi membrane. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and retina. Orthologous to human TMEM59L (transmembrane protein 59 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 122.7), cortex adult (RPKM 82.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem59l in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70936505..70939998, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70483855..70487348, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene kelch-like 26 Neighboring gene STARR-positive B cell enhancer ABC_E1368 Neighboring gene RIKEN cDNA 1700020G03 gene Neighboring gene cytokine receptor-like factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutational analysis of genes with ureteric progenitor cell-specific expression in branching morphogenesis of the mouse kidney. Rutledge EA, et al. Dev Dyn, 2020 Jun. PMID 32017326, Free PMC Article
  2. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
  3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2)  1 citation
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in branching involved in ureteric bud morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
transmembrane protein 59-like
Names
brain-specific membrane-anchored protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368366.1 → NP_001355295.1  transmembrane protein 59-like isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC157774

  2. NM_001368367.1 → NP_001355296.1  transmembrane protein 59-like isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC157774

  3. NM_182991.3 → NP_892036.1  transmembrane protein 59-like isoform 1 precursor

    See identical proteins and their annotated locations for NP_892036.1

    Status: VALIDATED

    Source sequence(s)
    AC157774
    Consensus CDS
    CCDS22368.1
    UniProtKB/Swiss-Prot
    Q7TNI2
    Related
    ENSMUSP00000043659.8, ENSMUST00000045286.9
    Conserved Domains (1) summary
    pfam12280
    Location:72 → 278
    BSMAP; Brain specific membrane anchored protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70936505..70939998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNI2.1 GenPept UniProtKB/Swiss-Prot:Q7TNI2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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