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Ces5a carboxylesterase 5A [ Mus musculus (house mouse) ]

Gene ID: 67935, updated on 2-Nov-2024

Summary

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Official Symbol
Ces5aprovided by MGI
Official Full Name
carboxylesterase 5Aprovided by MGI
Primary source
MGI:MGI:1915185
See related
Ensembl:ENSMUSG00000058019 AllianceGenome:MGI:1915185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ces7; Gm503; cauxin; 1700081L16Rik; 1700122C07Rik
Summary
Predicted to enable carboxylesterase activity. Predicted to be located in extracellular region. Orthologous to human CES5A (carboxylesterase 5A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward genital fat pad adult (RPKM 296.4) See more
Orthologs
human all
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Genomic context

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See Ces5a in Genome Data Viewer
Location:
8 C5; 8 45.67 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (94225691..94262507, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93499063..93535879, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22334 Neighboring gene STARR-seq mESC enhancer starr_22335 Neighboring gene carboxylesterase 1H Neighboring gene STARR-seq mESC enhancer starr_22336 Neighboring gene predicted gene, 30132 Neighboring gene STARR-seq mESC enhancer starr_22337 Neighboring gene STARR-seq mESC enhancer starr_22338 Neighboring gene STARR-seq mESC enhancer starr_22339 Neighboring gene predicted gene, 26843 Neighboring gene STARR-seq mESC enhancer starr_22341 Neighboring gene predicted gene, 30606 Neighboring gene STARR-seq mESC enhancer starr_22342 Neighboring gene predicted gene, 39224

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Species-, sex-, and age-dependent urinary excretion of cauxin, a mammalian carboxylesterase. Miyazaki M, et al. Comp Biochem Physiol B Biochem Mol Biol, 2006 Nov-Dec. PMID 17045831
  2. Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets. Robertson MJ, et al. BMC Biol, 2020 Aug 19. PMID 32814578, Free PMC Article
  3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
  4. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxylesterase 5A
Names
carboxylesterase 7
carboxylesterase-like urinary excreted protein homolog
NP_001003951.1
NP_001368779.1
XP_006531384.1
XP_006531385.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003951.3 → NP_001003951.1  carboxylesterase 5A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001003951.1

    Status: VALIDATED

    Source sequence(s)
    AC124591, AC162945
    Consensus CDS
    CCDS85584.1
    UniProtKB/Swiss-Prot
    Q6AW46
    Related
    ENSMUSP00000148481.2, ENSMUST00000212009.2
    Conserved Domains (2) summary
    COG0657
    Location:126 → 229
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:31 → 539
    COesterase; Carboxylesterase family

  2. NM_001381850.1 → NP_001368779.1  carboxylesterase 5A isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC124591, AC162945
    Conserved Domains (1) summary
    pfam00135
    Location:33 → 543
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    94225691..94262507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531321.3 → XP_006531384.1  carboxylesterase 5A isoform X1

    Conserved Domains (1) summary
    cl21494
    Location:35 → 452
    Abhydrolase; alpha/beta hydrolases

  2. XM_006531322.5 → XP_006531385.1  carboxylesterase 5A isoform X2

    Conserved Domains (1) summary
    pfam00135
    Location:1 → 423
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AW46.1 GenPept UniProtKB/Swiss-Prot:Q6AW46

Gene LinkOut

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