macroh2a1 macroH2A.1 histone [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: macroh2a1provided by ZNC
Official Full Name: macroH2A.1 histoneprovided by ZNC
Primary source: ZFIN:ZDB-GENE-060421-4796
See related: Ensembl:ENSDARG00000099329 AllianceGenome:ZFIN:ZDB-GENE-060421-4796
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: h2afy; fa93c12; wu:fa93c12; zgc:136891
Summary: Predicted to be a structural constituent of chromatin. Predicted to be involved in heterochromatin formation; negative regulation of transcription by RNA polymerase II; and negative regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to act upstream of or within chromatin organization. Predicted to be located in chromosome. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to human MACROH2A1 (macroH2A.1 histone). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (45758498..45769455)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (45538226..45549314, complement)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish macroH2A variants have distinct embryo localization and function.
Title: Zebrafish macroH2A variants have distinct embryo localization and function.

Submit: New GeneRIF Correction

General gene information

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Markers

fk93e08.x1 (e-PCR)
- UniSTS:201736

fa93c12.x1 (e-PCR)
- UniSTS:202578

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nucleosome assembly	IEA Inferred from Electronic Annotation more info
involved_in nucleosome assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: core histone macro-H2A.1

Names: H2A histone family, member Y; H2A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040361.1 → NP_001035451.1 core histone macro-H2A.1

See identical proteins and their annotated locations for NP_001035451.1

Status: PROVISIONAL

Source sequence(s)

BC115314

UniProtKB/TrEMBL

A0A0R4IX65, A0A8M9PCT2, Q1RLR9

Related

ENSDARP00000135218.1, ENSDART00000162548.2

Conserved Domains (2) summary

cd00074
Location:5 → 117

H2A; Histone 2A; H2A is a subunit of the nucleosome. The nucleosome is an octamer containing two H2A, H2B, H3, and H4 subunits. The H2A subunit performs essential roles in maintaining structural integrity of the nucleosome, chromatin condensation, and binding ...

cd02904
Location:170 → 349

Macro_H2A_like; Macro domain, Macro_H2A_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...