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cacnb4b calcium channel, voltage-dependent, beta 4b subunit [ Danio rerio (zebrafish) ]

Gene ID: 678560, updated on 2-Nov-2024

Summary

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Official Symbol
cacnb4bprovided by ZNC
Official Full Name
calcium channel, voltage-dependent, beta 4b subunitprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060421-7907
See related
Ensembl:ENSDARG00000062174 AllianceGenome:ZFIN:ZDB-GENE-060421-7907
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
CAB4b; cacnb4.1; zgc:136550
Summary
Enables voltage-gated calcium channel activity. Acts upstream of or within calcium ion transmembrane transport and epiboly involved in gastrulation with mouth forming second. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including atrium; head; nervous system; pleuroperitoneal region; and spinal cord neural tube. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cacnb4b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (14086331..14147008, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (13956894..14017542, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103911185 Neighboring gene grancalcin Neighboring gene ETS variant transcription factor 5b Neighboring gene inositol polyphosphate-4-phosphatase type I Ab Neighboring gene transmembrane protein 182b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish CaV2.1 calcium channels are tailored for fast synchronous neuromuscular transmission. Naranjo D, et al. Biophys J, 2015 Feb 3. PMID 25650925, Free PMC Article
  2. Zebrafish calls for reinterpretation for the roles of P/Q calcium channels in neuromuscular transmission. Wen H, et al. J Neurosci, 2013 Apr 24. PMID 23616544, Free PMC Article
  3. Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Zhou W, et al. Dev Dyn, 2008 Dec. PMID 19035348
  4. Ca2+ channel-independent requirement for MAGUK family CACNB4 genes in initiation of zebrafish epiboly. Ebert AM, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18172207, Free PMC Article
  5. Functional enrichment analysis based on long noncoding RNA associations. Hung KS, et al. BMC Syst Biol, 2018 Apr 24. PMID 29745842, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC136550

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within epiboly involved in gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit beta-4b
Names
voltage-dependent calcium channel beta 4 subunit
voltage-gated calcium channel beta-4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040318.3 → NP_001035408.2  voltage-dependent L-type calcium channel subunit beta-4b isoform 1

    See identical proteins and their annotated locations for NP_001035408.2

    Status: PROVISIONAL

    Source sequence(s)
    EF601057
    UniProtKB/TrEMBL
    A0A8M1N8R0, B0F0C6
    Related
    ENSDARP00000084010.3, ENSDART00000089577.5
    Conserved Domains (4) summary
    pfam00625
    Location:178 → 358
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:16 → 57
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:69 → 128
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:188 → 359
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

  2. NM_001113516.1 → NP_001106988.1  voltage-dependent L-type calcium channel subunit beta-4b isoform 2

    See identical proteins and their annotated locations for NP_001106988.1

    Status: PROVISIONAL

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    EF601062
    UniProtKB/TrEMBL
    A0A8M1NF57, B0F0D1
    Related
    ENSDARP00000083997.4, ENSDART00000089564.6
    Conserved Domains (4) summary
    pfam00625
    Location:212 → 392
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:50 → 91
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:103 → 162
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:222 → 393
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    14086331..14147008 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021476925.2 → XP_021332600.1  voltage-dependent L-type calcium channel subunit beta-4b isoform X1

    UniProtKB/TrEMBL
    A0A8M9QFI8
    Conserved Domains (3) summary
    pfam12052
    Location:50 → 91
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:103 → 162
    SH3; Src Homology 3 domain superfamily
    cl27059
    Location:195 → 375
    Guanylate_kin; Guanylate kinase

  2. XM_009302267.4 → XP_009300542.1  voltage-dependent L-type calcium channel subunit beta-4b isoform X2

    See identical proteins and their annotated locations for XP_009300542.1

    UniProtKB/TrEMBL
    T2B3N4
    Conserved Domains (4) summary
    pfam00625
    Location:161 → 341
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:16 → 57
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:69 → 128
    SH3; Src Homology 3 domain superfamily
    cl17190
    Location:171 → 342
    NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394628.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    232412..244670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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