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Ddx55 DEAD box helicase 55 [ Mus musculus (house mouse) ]

Gene ID: 67848, updated on 2-Nov-2024

Summary

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Official Symbol
Ddx55provided by MGI
Official Full Name
DEAD box helicase 55provided by MGI
Primary source
MGI:MGI:1915098
See related
Ensembl:ENSMUSG00000029389 AllianceGenome:MGI:1915098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1595; 2810021H22Rik
Summary
Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and RNA helicase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human DDX55 (DEAD-box helicase 55). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.5), CNS E18 (RPKM 5.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ddx55 in Genome Data Viewer
Location:
5 63.66 cM; 5 F
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (124690895..124707723)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (124552832..124569660)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein-like 1 Neighboring gene ribosomal protein L32 5C pseudogene Neighboring gene transmembrane p24 trafficking protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3619 Neighboring gene STARR-positive B cell enhancer ABC_E3620 Neighboring gene eukaryotic translation initiation factor 2B, subunit alpha Neighboring gene STARR-positive B cell enhancer ABC_E8083 Neighboring gene general transcription factor IIH, polypeptide 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The trafficking protein Tmed2/p24beta(1) is required for morphogenesis of the mouse embryo and placenta. Jerome-Majewska LA, et al. Dev Biol, 2010 May 1. PMID 20178780, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC143677, MGC143678

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent RNA helicase DDX55
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 55
DEAD box protein 55
NP_001177724.1
NP_080685.2
XP_036021336.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190795.1 → NP_001177724.1  ATP-dependent RNA helicase DDX55 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    BC043052, BY202366
    Consensus CDS
    CCDS57380.1
    UniProtKB/TrEMBL
    E9Q9T6, Q810A4
    Related
    ENSMUSP00000107065.2, ENSMUST00000111438.2
    Conserved Domains (4) summary
    COG0513
    Location:2 → 513
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cd00268
    Location:9 → 224
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:252 → 363
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:399 → 458
    DUF4217; Domain of unknown function (DUF4217)

  2. NM_026409.4 → NP_080685.2  ATP-dependent RNA helicase DDX55 isoform 1

    See identical proteins and their annotated locations for NP_080685.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK033741, BC043052, BY202366
    Consensus CDS
    CCDS39281.1
    UniProtKB/Swiss-Prot
    Q149H5, Q3U460, Q6ZPL9, Q8BZR1
    UniProtKB/TrEMBL
    Q810A4
    Related
    ENSMUSP00000070279.8, ENSMUST00000071057.14
    Conserved Domains (4) summary
    smart00487
    Location:24 → 228
    DEXDc; DEAD-like helicases superfamily
    cd00268
    Location:9 → 224
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:252 → 363
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:403 → 462
    DUF4217; Domain of unknown function (DUF4217)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    124690895..124707723
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165443.1 → XP_036021336.1  ATP-dependent RNA helicase DDX55 isoform X1

    Conserved Domains (2) summary
    COG0513
    Location:16 → 231
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam13959
    Location:258 → 315
    DUF4217; Domain of unknown function (DUF4217)

RNA

  1. XR_387576.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZPL9.2 GenPept UniProtKB/Swiss-Prot:Q6ZPL9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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