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SULT1E1 sulfotransferase family 1E member 1 [ Homo sapiens (human) ]

Gene ID: 6783, updated on 5-Mar-2024

Summary

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Official Symbol
SULT1E1provided by HGNC
Official Full Name
sulfotransferase family 1E member 1provided by HGNC
Primary source
HGNC:HGNC:11377
See related
Ensembl:ENSG00000109193 MIM:600043; AllianceGenome:HGNC:11377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EST; STE; EST-1; ST1E1
Summary
Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a protein that transfers a sulfo moiety to and from estrone, which may control levels of estrogen receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in small intestine (RPKM 11.9), duodenum (RPKM 11.7) and 4 other tissues See more
Orthologs
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Genomic context

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Location:
4q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (69821122..69860145, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (73176039..73194989, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (70706930..70725863, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1B member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70608551-70609050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609253-70609754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:70609755-70610254 Neighboring gene sulfotransferase family 1D member 1, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21599 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15467 Neighboring gene Sharpr-MPRA regulatory region 10246 Neighboring gene casein alpha s1 Neighboring gene casein beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase. Sato A, et al. Protein J, 2021 Apr. PMID 33665770
  2. Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17β-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes. El Daibani AA, et al. Eur J Drug Metab Pharmacokinet, 2021 Jan. PMID 33064293, Free PMC Article
  3. Inherited Variants in SULT1E1 and Response to Abiraterone Acetate by Men with Metastatic Castration Refractory Prostate Cancer. Agarwal N, et al. J Urol, 2016 Oct. PMID 27150425
  4. In Silico Prediction of Human Sulfotransferase 1E1 Activity Guided by Pharmacophores from Molecular Dynamics Simulations. Rakers C, et al. J Biol Chem, 2016 Jan 1. PMID 26542807, Free PMC Article
  5. New diterpenoids with estrogen sulfotransferase inhibitory activity from Leonurus sibiricus L. Narukawa Y, et al. J Nat Med, 2014 Jan. PMID 23736977

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours.
    Title: Estrogen Sulfotransferase SULT1E1 Expression Levels and Regulated Factors in Malignant Tumours.
  2. Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques.
    Title: Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques.
  3. Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
    Title: Interaction of Native- and Oxidized-Low-Density Lipoprotein with Human Estrogen Sulfotransferase.
  4. Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17beta-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes.
    Title: Impact of Human SULT1E1 Polymorphisms on the Sulfation of 17β-Estradiol, 4-Hydroxytamoxifen, and Diethylstilbestrol by SULT1E1 Allozymes.
  5. CYP19A1 mRNA levels were lower in endometrial cancer (EC) than in controls. A novel highly sensitive and accurate protocol to assess SULT1E1 activity is presented. STS enzyme activity and the STS:SULT1E1 activity ratio seem to be lower in ECs than in controls. STS is an important route for estrogen supply in endometrial cells.
    Title: The sulfatase pathway as estrogen supply in endometrial cancer.
  6. Increased expression of SULT1E1 is associated with obstructive cholestasis.
    Title: Cholestasis-induced bile acid elevates estrogen level via farnesoid X receptor-mediated suppression of the estrogen sulfotransferase SULT1E1.
  7. Galeterone and abiraterone are novel inhibitors of DHEA sulfonation, as determined in enzymatic incubations containing human tissue cytosol (liver or intestinal) or human recombinant SULT enzyme (SULT2A1, SULT2B1b, or SULT1E1).
    Title: Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1.
  8. Single nucleotide polymorphisms in SULT1E1 were significantly associated with time to treatment failure in men on abiraterone acetate therapy. The single nucleotide polymorphisms may serve as predictive markers for treatment with abiraterone acetate.
    Title: Inherited Variants in SULT1E1 and Response to Abiraterone Acetate by Men with Metastatic Castration Refractory Prostate Cancer.
  9. Resveratrol and all its derivatives reduced also SULT1E1 mRNA transcript level. The reduced expression of AhR, CYP1A1, and 1B1 was also found as a result of treatment with these compounds.
    Title: Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation.
  10. Data show that both estrogen sulfatase (STS) and estrogen sulfotransferase (EST) were highly expressed in the human umbilical vein
    Title: Melatonin affects the dynamic steady-state equilibrium of estrogen sulfates in human umbilical vein endothelial cells by regulating the balance between estrogen sulfatase and sulfotransferase.
Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC34459

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aryl sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables estrone sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables flavonol 3-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
  
enables steroid sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in estrogen catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in estrogen metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ethanol catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in steroid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in sulfation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sulfation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
sulfotransferase 1E1
Names
estrogen sulfotransferase
estrone sulfotransferase
sulfotransferase family 1E, estrogen-preferring, member 1
sulfotransferase, estrogen-preferring
NP_005411.1
XP_011530512.1
XP_047272056.1
XP_047272057.1
XP_054206726.1
XP_054206727.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005420.3 → NP_005411.1  sulfotransferase 1E1

    See identical proteins and their annotated locations for NP_005411.1

    Status: REVIEWED

    Source sequence(s)
    AC108941
    Consensus CDS
    CCDS3531.1
    UniProtKB/Swiss-Prot
    P49888, Q8N6X5
    UniProtKB/TrEMBL
    Q53X91
    Related
    ENSP00000226444.3, ENST00000226444.4
    Conserved Domains (1) summary
    pfam00685
    Location:37 → 287
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    69821122..69860145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416101.1 → XP_047272057.1  sulfotransferase 1E1 isoform X1

    UniProtKB/Swiss-Prot
    P49888, Q8N6X5
    UniProtKB/TrEMBL
    Q53X91

  2. XM_047416100.1 → XP_047272056.1  sulfotransferase 1E1 isoform X1

    UniProtKB/Swiss-Prot
    P49888, Q8N6X5
    UniProtKB/TrEMBL
    Q53X91

  3. XM_011532210.3 → XP_011530512.1  sulfotransferase 1E1 isoform X2

    Conserved Domains (1) summary
    pfam00685
    Location:37 → 165
    Sulfotransfer_1; Sulfotransferase domain

RNA

  1. XR_007057952.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    73176039..73194989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350751.1 → XP_054206726.1  sulfotransferase 1E1 isoform X1

    UniProtKB/Swiss-Prot
    P49888, Q8N6X5
    UniProtKB/TrEMBL
    Q53X91

  2. XM_054350752.1 → XP_054206727.1  sulfotransferase 1E1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49888.1 GenPept UniProtKB/Swiss-Prot:P49888

Gene LinkOut

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