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Nmral1 NmrA-like family domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 67824, updated on 2-Nov-2024

Summary

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Official Symbol
Nmral1provided by MGI
Official Full Name
NmrA-like family domain containing 1provided by MGI
Primary source
MGI:MGI:1915074
See related
Ensembl:ENSMUSG00000063445 AllianceGenome:MGI:1915074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110025F24Rik
Summary
Predicted to enable identical protein binding activity. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and lung. Orthologous to human NMRAL1 (NmrA like redox sensor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 36.3), CNS E14 (RPKM 19.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Nmral1 in Genome Data Viewer
Location:
16 A1; 16 2.46 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (4529181..4537220, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (4711317..4719356, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene STARR-positive B cell enhancer ABC_E10885 Neighboring gene STARR-seq mESC enhancer starr_39941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4683706-4683859 Neighboring gene STARR-seq mESC enhancer starr_39942 Neighboring gene DnaJ heat shock protein family (Hsp40) member A3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:4726231-4726340 Neighboring gene heme oxygenase 2 Neighboring gene STARR-seq mESC enhancer starr_39943 Neighboring gene cell death inducing Trp53 target 1 Neighboring gene STARR-positive B cell enhancer ABC_E7425 Neighboring gene STARR-seq mESC enhancer starr_39945 Neighboring gene RIKEN cDNA 4930562C15 gene Neighboring gene predicted gene, 36513

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development. Ajioka I, et al. Eur J Neurosci, 2006 Jan. PMID 16420439
  2. The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein. Phan LK, et al. J Clin Invest, 2002 Nov. PMID 12438443, Free PMC Article
  3. Epilepsy- and intellectual disability-associated CYFIP2 interacts with both actin regulators and RNA-binding proteins in the neonatal mouse forebrain. Lee Y, et al. Biochem Biophys Res Commun, 2020 Aug 13. PMID 32560809
  4. Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Zang W, et al. Proc Natl Acad Sci U S A, 2019 Dec 17. PMID 31796584, Free PMC Article
  5. Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling. Wilkinson B, et al. Sci Rep, 2017 Jul 13. PMID 28706196, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nmrA-like family domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290761.1 → NP_001277690.1  nmrA-like family domain-containing protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter compared to isoform 1.
    Source sequence(s)
    AK146521, BC030039, BX527978
    Consensus CDS
    CCDS70678.1
    UniProtKB/TrEMBL
    D3YU12
    Related
    ENSMUSP00000112754.2, ENSMUST00000120056.8
    Conserved Domains (2) summary
    cd05251
    Location:7 → 238
    NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
    COG0702
    Location:5 → 206
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

  2. NM_001290762.1 → NP_001277691.1  nmrA-like family domain-containing protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001277691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 3, which has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA166262, AK012340, AK146521, BC030039, BX527978
    Consensus CDS
    CCDS70679.1
    UniProtKB/TrEMBL
    G5E8S7
    Related
    ENSMUSP00000111517.4, ENSMUST00000115851.10
    Conserved Domains (2) summary
    cd05251
    Location:7 → 241
    NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
    COG0702
    Location:5 → 206
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

  3. NM_001290763.1 → NP_001277692.1  nmrA-like family domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001277692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK078389, BX527978
    Consensus CDS
    CCDS70680.1
    UniProtKB/Swiss-Prot
    Q8K2T1
    Related
    ENSMUSP00000074500.8, ENSMUST00000074970.8
    Conserved Domains (2) summary
    cd05251
    Location:7 → 238
    NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
    COG0702
    Location:5 → 206
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

  4. NM_026393.2 → NP_080669.1  nmrA-like family domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_080669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC030039, BX527978
    Consensus CDS
    CCDS27923.1
    UniProtKB/Swiss-Prot
    Q8BVF0, Q8K2T1, Q9CZP2
    Related
    ENSMUSP00000078132.8, ENSMUST00000079130.14
    Conserved Domains (2) summary
    cd05251
    Location:7 → 248
    NmrA_like_SDR_a; NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs
    COG0702
    Location:5 → 216
    YbjT; Uncharacterized conserved protein YbjT, contains NAD(P)-binding and DUF2867 domains [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    4529181..4537220 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K2T1.1 GenPept UniProtKB/Swiss-Prot:Q8K2T1

Gene LinkOut

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