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Sec14l2 SEC14-like lipid binding 2 [ Mus musculus (house mouse) ]

Gene ID: 67815, updated on 2-Nov-2024

Summary

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Official Symbol
Sec14l2provided by MGI
Official Full Name
SEC14-like lipid binding 2provided by MGI
Primary source
MGI:MGI:1915065
See related
Ensembl:ENSMUSG00000003585 AllianceGenome:MGI:1915065
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Spf; TAP; 1300013M05Rik
Summary
Predicted to enable enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to be involved in positive regulation of cholesterol biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in 1st branchial arch maxillary component; nasal pit; otocyst; and trunk somite. Orthologous to human SEC14L2 (SEC14 like lipid binding 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver adult (RPKM 140.8), liver E18 (RPKM 27.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Sec14l2 in Genome Data Viewer
Location:
11 A1; 11 2.87 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4047039..4068729, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4097039..4118729, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SEC14-like lipid binding 3 Neighboring gene predicted gene, 51935 Neighboring gene STARR-seq mESC enhancer starr_28370 Neighboring gene mitochondrial fission process 1 Neighboring gene predicted gene, 51934 Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. Shibata N, et al. FASEB J, 2006 Dec. PMID 17077281
  2. Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. Caras IW, et al. J Biol Chem, 1980 Apr 25. PMID 7364757
  3. A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. Zimmer S, et al. J Biol Chem, 2000 Aug 18. PMID 10829015
  4. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Shibata N, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226224, Free PMC Article
  5. Tocopherol-associated protein is a ligand-dependent transcriptional activator. Yamauchi J, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444841

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme activator activity ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SEC14-like protein 2
Names
SEC14-like 2
alpha-tocopherol-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144520.2 → NP_653103.1  SEC14-like protein 2

    See identical proteins and their annotated locations for NP_653103.1

    Status: PROVISIONAL

    Source sequence(s)
    AL807395
    Consensus CDS
    CCDS24377.1
    UniProtKB/Swiss-Prot
    Q99J08
    Related
    ENSMUSP00000003681.8, ENSMUST00000003681.8
    Conserved Domains (3) summary
    smart00516
    Location:76 → 244
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:13 → 59
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
    pfam13897
    Location:300 → 381
    GOLD_2; Golgi-dynamics membrane-trafficking

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    4047039..4068729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J08.1 GenPept UniProtKB/Swiss-Prot:Q99J08

Gene LinkOut

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