U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rgs8 regulator of G-protein signaling 8 [ Mus musculus (house mouse) ]

Gene ID: 67792, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Rgs8provided by MGI
Official Full Name
regulator of G-protein signaling 8provided by MGI
Primary source
MGI:MGI:108408
See related
Ensembl:ENSMUSG00000042671 AllianceGenome:MGI:108408
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6530413N01Rik
Summary
Predicted to enable G-protein alpha-subunit binding activity and GTPase activator activity. Predicted to be involved in G protein-coupled acetylcholine receptor signaling pathway; positive regulation of GTPase activity; and regulation of dopamine receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and neuronal cell body membrane. Is expressed in central nervous system and retina. Orthologous to human RGS8 (regulator of G protein signaling 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 84.0), cortex adult (RPKM 9.6) and 4 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rgs8 in Genome Data Viewer
Location:
1 G3; 1 65.41 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (153528612..153573415)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (153652959..153697669)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02701 Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene STARR-seq mESC enhancer starr_02703 Neighboring gene STARR-seq mESC enhancer starr_02704 Neighboring gene STARR-seq mESC enhancer starr_02705 Neighboring gene predicted gene 6652 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155538364-155538664 Neighboring gene STARR-positive B cell enhancer mm9_chr1:155543174-155543475 Neighboring gene RIKEN cDNA C230024C17 gene Neighboring gene regulator of G-protein signaling 16

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8). Kobayashi Y, et al. Neuroscience, 2018 Jul 15. PMID 29758252
  2. Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY. Taylor VG, et al. J Biol Chem, 2016 Mar 4. PMID 26755720, Free PMC Article
  3. Generation of RGS8 null mutant mice by Cre/loxP system. Kuwata H, et al. Kobe J Med Sci, 2008 Feb 8. PMID 18762722
  4. Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model. Dansithong W, et al. PLoS Genet, 2015 Apr. PMID 25902068, Free PMC Article
  5. Altered Purkinje cell miRNA expression and SCA1 pathogenesis. Rodriguez-Lebron E, et al. Neurobiol Dis, 2013 Jun. PMID 23376683, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these findings suggest that RGS8 participates in modulation of depression-like behavior
    Title: Depression-resistant Phenotype in Mice Overexpressing Regulator of G Protein Signaling 8 (RGS8).
  2. the crystal structure of RGS8 was determined in complex with Galphaq.
    Title: Structure of the Regulator of G Protein Signaling 8 (RGS8)-Gαq Complex: MOLECULAR BASIS FOR Gα SELECTIVITY.
  3. ATXN2 interacted selectively with RGS8 mRNA. This interaction was impaired when ATXN2 harbored an expanded polyglutamine. Mutant ATXN2 also reduced RGS8 expression in an in vitro coupled translation
    Title: Ataxin-2 regulates RGS8 translation in a new BAC-SCA2 transgenic mouse model.
  4. increased miR-150 levels in Spinocerebellar ataxia type 1 Purkinje neurons may modulate disease pathogenesis by targeting the expression of Rgs8 and Vegfa.
    Title: Altered Purkinje cell miRNA expression and SCA1 pathogenesis.
  5. RGS8 null mutant mice were viable, fertile and showed apparently normal development
    Title: Generation of RGS8 null mutant mice by Cre/loxP system.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activator activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dopamine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
regulator of G-protein signaling 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347115.1 → NP_001334044.1  regulator of G-protein signaling 8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154140, CF741546
    Consensus CDS
    CCDS83607.1
    UniProtKB/TrEMBL
    D3Z289
    Related
    ENSMUSP00000107445.2, ENSMUST00000111814.8
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  2. NM_001357525.1 → NP_001344454.1  regulator of G-protein signaling 8 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154140
    Consensus CDS
    CCDS15375.1
    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Related
    ENSMUSP00000107443.2, ENSMUST00000111812.8
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  3. NM_026380.3 → NP_080656.2  regulator of G-protein signaling 8 isoform 1

    See identical proteins and their annotated locations for NP_080656.2

    Status: VALIDATED

    Source sequence(s)
    BC065056, BY292997
    Consensus CDS
    CCDS15375.1
    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Related
    ENSMUSP00000045715.6, ENSMUST00000041776.12
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    153528612..153573415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529822.5 → XP_006529885.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006529885.1

    UniProtKB/TrEMBL
    D3Z289
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  2. XM_006529829.5 → XP_006529892.1  regulator of G-protein signaling 8 isoform X3

    Conserved Domains (1) summary
    cl02565
    Location:10 → 134
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  3. XM_006529821.3 → XP_006529884.1  regulator of G-protein signaling 8 isoform X1

    See identical proteins and their annotated locations for XP_006529884.1

    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  4. XM_006529826.4 → XP_006529889.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006529889.1

    UniProtKB/TrEMBL
    D3Z289
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  5. XM_030242505.1 → XP_030098365.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Related
    ENSMUSP00000107441.2, ENSMUST00000111810.2
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  6. XM_006529828.3 → XP_006529891.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006529891.1

    UniProtKB/TrEMBL
    D3Z289
    Related
    ENSMUSP00000107446.2, ENSMUST00000111815.8
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  7. XM_030242507.2 → XP_030098367.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  8. XM_006529827.4 → XP_006529890.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006529890.1

    UniProtKB/TrEMBL
    D3Z289
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  9. XM_006529825.4 → XP_006529888.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006529888.1

    UniProtKB/TrEMBL
    D3Z289
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  10. XM_006529824.5 → XP_006529887.1  regulator of G-protein signaling 8 isoform X2

    See identical proteins and their annotated locations for XP_006529887.1

    UniProtKB/TrEMBL
    D3Z289
    Conserved Domains (1) summary
    cd08711
    Location:44 → 168
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  11. XM_006529818.5 → XP_006529881.1  regulator of G-protein signaling 8 isoform X1

    See identical proteins and their annotated locations for XP_006529881.1

    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  12. XM_006529820.5 → XP_006529883.1  regulator of G-protein signaling 8 isoform X1

    See identical proteins and their annotated locations for XP_006529883.1

    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  13. XM_036153199.1 → XP_036009092.1  regulator of G-protein signaling 8 isoform X3

    Conserved Domains (1) summary
    cl02565
    Location:10 → 134
    RGS; Regulator of G protein signaling (RGS) domain superfamily

  14. XM_036153183.1 → XP_036009076.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    Q505F2, Q8BXT1
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BXT1.1 GenPept UniProtKB/Swiss-Prot:Q8BXT1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous