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Vwa5a von Willebrand factor A domain containing 5A [ Mus musculus (house mouse) ]

Gene ID: 67776, updated on 2-Nov-2024

Summary

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Official Symbol
Vwa5aprovided by MGI
Official Full Name
von Willebrand factor A domain containing 5Aprovided by MGI
Primary source
MGI:MGI:1915026
See related
Ensembl:ENSMUSG00000023186 AllianceGenome:MGI:1915026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BCSC-1; Loh11cr2a; E130119J22; 5830475I06Rik
Summary
Predicted to be an extracellular matrix structural constituent. Located in collagen-containing extracellular matrix. Orthologous to human VWA5A (von Willebrand factor A domain containing 5A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 18.6), mammary gland adult (RPKM 11.6) and 27 other tissues See more
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Genomic context

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See Vwa5a in Genome Data Viewer
Location:
9 A5.1; 9 20.89 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (38629564..38654633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (38718268..38743337)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor GA_x5J8B7W60AJ-925630-926226 Neighboring gene olfactory receptor family 8 subfamily G member 51 Neighboring gene olfactory receptor family 8 subfamily B member 53 Neighboring gene olfactory receptor family 8 subfamily B member 54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene. Martin ES, et al. Proc Natl Acad Sci U S A, 2003 Sep 30. PMID 14504409, Free PMC Article
  2. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
  3. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  4. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Naba A, et al. Mol Cell Proteomics, 2012 Apr. PMID 22159717, Free PMC Article
  5. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Naba A, et al. Sci Rep, 2017 Jan 10. PMID 28071719, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
von Willebrand factor A domain-containing protein 5A
Names
loss of heterozygosity, 11, chromosomal region 2, gene A homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145957.1 → NP_001139429.1  von Willebrand factor A domain-containing protein 5A

    See identical proteins and their annotated locations for NP_001139429.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK161193, AY366502, BB856505
    Consensus CDS
    CCDS23024.1
    UniProtKB/Swiss-Prot
    Q3TTU2, Q3UVU1, Q3V3F2, Q6UN22, Q8BHA8, Q99KC8, Q9CTV9
    Related
    ENSMUSP00000113596.2, ENSMUST00000118144.8
    Conserved Domains (3) summary
    smart00609
    Location:1 → 131
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:279 → 456
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:20 → 617
    marine_srt_targ; marine proteobacterial sortase target protein

  2. NM_172767.3 → NP_766355.3  von Willebrand factor A domain-containing protein 5A

    See identical proteins and their annotated locations for NP_766355.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK054497, AK136934, AY366502, BB856505
    Consensus CDS
    CCDS23024.1
    UniProtKB/Swiss-Prot
    Q3TTU2, Q3UVU1, Q3V3F2, Q6UN22, Q8BHA8, Q99KC8, Q9CTV9
    Related
    ENSMUSP00000001544.6, ENSMUST00000001544.12
    Conserved Domains (3) summary
    smart00609
    Location:1 → 131
    VIT; Vault protein Inter-alpha-Trypsin domain
    cd01461
    Location:279 → 456
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    TIGR03788
    Location:20 → 617
    marine_srt_targ; marine proteobacterial sortase target protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    38629564..38654633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KC8.2 GenPept UniProtKB/Swiss-Prot:Q99KC8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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