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Slc25a26 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 [ Mus musculus (house mouse) ]

Gene ID: 67582, updated on 2-Nov-2024

Summary

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Official Symbol
Slc25a26provided by MGI
Official Full Name
solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26provided by MGI
Primary source
MGI:MGI:1914832
See related
Ensembl:ENSMUSG00000045100 AllianceGenome:MGI:1914832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slc25a6; D6Bwg0781e; 4930433D19Rik; 4933433F13Rik
Summary
Predicted to enable S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity. Predicted to be involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 4.5), heart adult (RPKM 4.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc25a26 in Genome Data Viewer
Location:
6 D2; 6 43.13 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (94477272..94581636)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (94500295..94604659)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16710 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16711 Neighboring gene microRNA 7041 Neighboring gene leucine-rich repeats and immunoglobulin-like domains 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:94587371-94587480 Neighboring gene VISTA enhancer mm1736 Neighboring gene prefoldin 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice. Cheng GP, et al. Oxid Med Cell Longev, 2022. PMID 35464759, Free PMC Article
  2. Transposon vectors for gene-trap insertional mutagenesis in vertebrates. Clark KJ, et al. Genesis, 2004 Aug. PMID 15286994
  3. Conditional gene expression in the mouse using a Sleeping Beauty gene-trap transposon. Geurts AM, et al. BMC Biotechnol, 2006 Jun 26. PMID 16800892, Free PMC Article
  4. Transposon mutagenesis of the mouse germline. Carlson CM, et al. Genetics, 2003 Sep. PMID 14504232, Free PMC Article
  5. DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis. Li Y, et al. Blood, 2021 Dec 9. PMID 34255829, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice.
    Title: Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Transposon induced (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S-adenosyl-L-methionine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosyl-L-methionine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosyl-L-methionine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in L-alpha-amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosyl-L-methionine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in S-adenosyl-L-methionine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in macromolecule methylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of macromolecule methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial S-adenosyl-L-methionine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial S-adenosyl-L-methionine transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in purine nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial S-adenosylmethionine carrier protein
Names
S-adenosylmethionine mitochondrial carrier protein
SAM carrier
mitochondrial S-adenosylmethionine transporter
solute carrier family 25 member 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026255.5 → NP_080531.2  mitochondrial S-adenosylmethionine carrier protein

    See identical proteins and their annotated locations for NP_080531.2

    Status: VALIDATED

    Source sequence(s)
    AC122272, AK015299, BB852792, BU700917
    Consensus CDS
    CCDS20379.1
    UniProtKB/Swiss-Prot
    Q5U680, Q8JZT2
    Related
    ENSMUSP00000058028.9, ENSMUST00000061118.11
    Conserved Domains (2) summary
    PTZ00168
    Location:9 → 258
    PTZ00168; mitochondrial carrier protein; Provisional
    pfam00153
    Location:2 → 82
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    94477272..94581636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506517.5 → XP_006506580.1  mitochondrial S-adenosylmethionine carrier protein isoform X1

    Conserved Domains (1) summary
    PTZ00168
    Location:9 → 243
    PTZ00168; mitochondrial carrier protein; Provisional

  2. XM_006506518.5 → XP_006506581.1  mitochondrial S-adenosylmethionine carrier protein isoform X2

    Conserved Domains (1) summary
    PTZ00168
    Location:9 → 207
    PTZ00168; mitochondrial carrier protein; Provisional

  3. XM_006506519.5 → XP_006506582.1  mitochondrial S-adenosylmethionine carrier protein isoform X3

    Conserved Domains (1) summary
    pfam00153
    Location:4 → 80
    Mito_carr; Mitochondrial carrier protein

  4. XM_006506523.5 → XP_006506586.1  mitochondrial S-adenosylmethionine carrier protein isoform X6

    Conserved Domains (1) summary
    PTZ00168
    Location:9 → 154
    PTZ00168; mitochondrial carrier protein; Provisional

  5. XM_036152276.1 → XP_036008169.1  mitochondrial S-adenosylmethionine carrier protein isoform X4

    Conserved Domains (1) summary
    PTZ00168
    Location:9 → 151
    PTZ00168; mitochondrial carrier protein; Provisional

  6. XM_011241446.4 → XP_011239748.1  mitochondrial S-adenosylmethionine carrier protein isoform X5

    Conserved Domains (1) summary
    pfam00153
    Location:4 → 80
    Mito_carr; Mitochondrial carrier protein

  7. XM_006506524.5 → XP_006506587.1  mitochondrial S-adenosylmethionine carrier protein isoform X7

    Conserved Domains (1) summary
    pfam00153
    Location:59 → 131
    Mito_carr; Mitochondrial carrier protein

RNA

  1. XR_003956252.2 RNA Sequence

  2. XR_868874.4 RNA Sequence

  3. XR_868875.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U680.2 GenPept UniProtKB/Swiss-Prot:Q5U680

Gene LinkOut

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