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C1qtnf4 C1q and tumor necrosis factor related protein 4 [ Mus musculus (house mouse) ]

Gene ID: 67445, updated on 28-Oct-2024

Summary

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Official Symbol
C1qtnf4provided by MGI
Official Full Name
C1q and tumor necrosis factor related protein 4provided by MGI
Primary source
MGI:MGI:1914695
See related
Ensembl:ENSMUSG00000040794 AllianceGenome:MGI:1914695
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adin; CTRP4; 0710001E10Rik; 9430004J15Rik
Summary
Predicted to enable cytokine activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway via STAT; protein phosphorylation; and reduction of food intake in response to dietary excess. Predicted to be active in extracellular space. Is expressed in brain and retina. Orthologous to human C1QTNF4 (C1q and TNF related 4). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 119.2), frontal lobe adult (RPKM 74.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See C1qtnf4 in Genome Data Viewer
Location:
2 E1; 2 50.43 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90713132..90720870)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90882788..90890526)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 2 Neighboring gene STARR-seq mESC enhancer starr_05097 Neighboring gene predicted gene 13772 Neighboring gene STARR-seq mESC enhancer starr_05098 Neighboring gene STARR-positive B cell enhancer ABC_E11147 Neighboring gene mitochondrial carrier 2 Neighboring gene STARR-positive B cell enhancer ABC_E9517 Neighboring gene predicted gene, 32514 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S3 Neighboring gene predicted gene, 54113

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock. Cao L, et al. Eur J Immunol, 2021 Feb. PMID 33080044
  2. Loss of CTRP4 alters adiposity and food intake behaviors in obese mice. Sarver DC, et al. Am J Physiol Endocrinol Metab, 2020 Dec 1. PMID 33017221, Free PMC Article
  3. C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake. Li Y, et al. Neuroscience, 2020 Mar 1. PMID 31917347
  4. Ctrp4, a new adipokine, promotes the differentiation of osteoblasts. Li Q, et al. Biochem Biophys Res Commun, 2019 Apr 30. PMID 30885436
  5. Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice. Luo Y, et al. Cell Mol Immunol, 2016 Sep. PMID 27086950, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-kappaB signaling and microglial activation.
    Title: C1q/TNF-related protein 4 restores leptin sensitivity by downregulating NF-κB signaling and microglial activation.
  2. C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake.
    Title: C1q/TNF-related Protein 4 Induces Signal Transducer and Activator of Transcription 3 Pathway and Modulates Food Intake.
  3. CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock.
    Title: CTRP4 acts as an anti-inflammatory factor in macrophages and protects against endotoxic shock.
  4. These results suggest that Ctrp4 is involved in bone metabolism regulation and promotes osteoblast differentiation, which may become a potential target for future intervention in bone metabolic diseases.
    Title: Ctrp4, a new adipokine, promotes the differentiation of osteoblasts.
  5. CTRP4 plays an important role in inflammation and inflammation-associated colon tumorigenesis.
    Title: Expression of the novel adipokine C1qTNF-related protein 4 (CTRP4) suppresses colitis and colitis-associated colorectal cancer in mice.
  6. These results establish CTRP4 as a novel nutrient-responsive central regulator of food intake and energy balance.
    Title: C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4)  1 citation
  • Targeted (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor signaling pathway via STAT IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within reduction of food intake in response to dietary excess IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 4
Names
C1q/TNF-related protein 4
adiponectin n

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026161.3 → NP_080437.2  complement C1q tumor necrosis factor-related protein 4 precursor

    See identical proteins and their annotated locations for NP_080437.2

    Status: VALIDATED

    Source sequence(s)
    AK029777, BF458176, CX243534, DQ002397
    Consensus CDS
    CCDS16417.2
    UniProtKB/Swiss-Prot
    A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
    UniProtKB/TrEMBL
    A0A3B0IP17
    Related
    ENSMUSP00000107091.3, ENSMUST00000111466.3
    Conserved Domains (1) summary
    pfam00386
    Location:30 → 155
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90713132..90720870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251995.1 → XP_030107855.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
    UniProtKB/TrEMBL
    A0A3B0IP17
    Conserved Domains (1) summary
    pfam00386
    Location:30 → 155
    C1q; C1q domain

  2. XM_006500080.4 → XP_006500143.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006500143.1

    UniProtKB/Swiss-Prot
    A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
    UniProtKB/TrEMBL
    A0A3B0IP17
    Conserved Domains (1) summary
    pfam00386
    Location:30 → 155
    C1q; C1q domain

  3. XM_006500079.2 → XP_006500142.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006500142.1

    UniProtKB/Swiss-Prot
    A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
    UniProtKB/TrEMBL
    A0A3B0IP17
    Conserved Domains (1) summary
    pfam00386
    Location:30 → 155
    C1q; C1q domain

  4. XM_030251994.2 → XP_030107854.1  complement C1q tumor necrosis factor-related protein 4 isoform X1

    UniProtKB/Swiss-Prot
    A2AFW1, Q4ZJN5, Q8R066, Q9D0W2, Q9DCB6
    UniProtKB/TrEMBL
    A0A3B0IP17
    Conserved Domains (1) summary
    pfam00386
    Location:30 → 155
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R066.1 GenPept UniProtKB/Swiss-Prot:Q8R066

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