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Dedd2 death effector domain-containing DNA binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 67379, updated on 2-Nov-2024

Summary

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Official Symbol
Dedd2provided by MGI
Official Full Name
death effector domain-containing DNA binding protein 2provided by MGI
Primary source
MGI:MGI:1914629
See related
Ensembl:ENSMUSG00000054499 AllianceGenome:MGI:1914629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLAME-3; 2410050E11Rik
Summary
Predicted to enable DNA binding activity. Predicted to be involved in apoptotic nuclear changes; extrinsic apoptotic signaling pathway via death domain receptors; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within apoptotic process and regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Orthologous to human DEDD2 (death effector domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 41.3), small intestine adult (RPKM 39.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dedd2 in Genome Data Viewer
Location:
7 A3; 7 13.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24899337..24920035, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25199912..25220614, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene POU domain, class 2, transcription factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E3704 Neighboring gene microRNA 6537 Neighboring gene STARR-seq mESC enhancer starr_18291 Neighboring gene STARR-positive B cell enhancer ABC_E2225 Neighboring gene STARR-positive B cell enhancer ABC_E6522 Neighboring gene STARR-positive B cell enhancer ABC_E3705 Neighboring gene RIKEN cDNA D930028M14 gene Neighboring gene STARR-seq mESC enhancer starr_18292 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25990365-25990647 Neighboring gene STARR-seq mESC enhancer starr_18294 Neighboring gene STARR-positive B cell enhancer ABC_E868 Neighboring gene STARR-positive B cell enhancer ABC_E1724 Neighboring gene RIKEN cDNA 9130221H12 gene Neighboring gene microRNA 7048 Neighboring gene zinc finger protein 526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26024418-26024601 Neighboring gene glycogen synthase kinase 3 alpha Neighboring gene STARR-positive B cell enhancer ABC_E3706 Neighboring gene Ets2 repressor factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The death effector domain protein family. Barnhart BC, et al. Oncogene, 2003 Nov 24. PMID 14634625
  2. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Alcivar A, et al. Oncogene, 2003 Jan 16. PMID 12527898
  3. Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC. Zhan Y, et al. Cell Death Differ, 2002 Apr. PMID 11965497
  4. Comparative analysis of apoptosis and inflammation genes of mice and humans. Reed JC, et al. Genome Res, 2003 Jun. PMID 12819136, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in apoptotic nuclear changes IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic nuclear changes ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
  
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of apoptotic process RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding death effector domain-containing protein 2
Names
DED-containing protein FLAME-3
FADD-like anti-apoptotic molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207677.3 → NP_997560.3  DNA-binding death effector domain-containing protein 2

    See identical proteins and their annotated locations for NP_997560.3

    Status: VALIDATED

    Source sequence(s)
    BC092250
    Consensus CDS
    CCDS20973.1
    UniProtKB/Swiss-Prot
    Q569Y9, Q8JZV1, Q8QZV0
    Related
    ENSMUSP00000049763.6, ENSMUST00000058702.7
    Conserved Domains (1) summary
    cl14633
    Location:14 → 118
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24899337..24920035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242925.2 → XP_030098785.1  DNA-binding death effector domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q569Y9, Q8JZV1, Q8QZV0
    Conserved Domains (1) summary
    cl14633
    Location:14 → 118
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_036153381.1 → XP_036009274.1  DNA-binding death effector domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q569Y9, Q8JZV1, Q8QZV0
    Related
    ENSMUST00000206750.2
    Conserved Domains (1) summary
    cl14633
    Location:14 → 118
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_003946545.2 RNA Sequence

  2. XR_391094.3 RNA Sequence

  3. XR_004934172.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026117.2: Suppressed sequence

    Description
    NM_026117.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZV0.1 GenPept UniProtKB/Swiss-Prot:Q8QZV0

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