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Dph7 diphthamine biosynethesis 7 [ Mus musculus (house mouse) ]

Gene ID: 67228, updated on 18-Sep-2024

Summary

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Official Symbol
Dph7provided by MGI
Official Full Name
diphthamine biosynethesis 7provided by MGI
Primary source
MGI:MGI:1914478
See related
Ensembl:ENSMUSG00000026975 AllianceGenome:MGI:1914478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wdr85; 2810443J12Rik
Summary
Predicted to enable diphthine methylesterase activity. Predicted to be involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Orthologous to human DPH7 (diphthamide biosynthesis 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 6.3), limb E14.5 (RPKM 6.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dph7 in Genome Data Viewer
Location:
2 A3; 2 16.87 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (24852183..24862198)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24962171..24972186)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E634 Neighboring gene arrestin domain containing 1 Neighboring gene zinc finger, MYND domain containing 19 Neighboring gene STARR-positive B cell enhancer ABC_E5898 Neighboring gene STARR-positive B cell enhancer ABC_E1001 Neighboring gene mitochondrial ribosomal protein L41 Neighboring gene patatin-like phospholipase domain containing 7 Neighboring gene ribosomal protein L21 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables diphthine methylesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diphthine methylesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein histidyl modification to diphthamide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein histidyl modification to diphthamide IEA
Inferred from Electronic Annotation
more info
  
involved_in protein histidyl modification to diphthamide ISO
Inferred from Sequence Orthology
more info
  
involved_in protein histidyl modification to diphthamide ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
diphthine methyltransferase
Names
WD repeat domain 85
WD repeat-containing protein 85
WD40 repeat domain 85
diphthamide biosynthesis protein 7
NP_001342483.1
NP_001342485.1
NP_001342486.1
NP_001342487.1
NP_001342488.1
NP_001342489.1
NP_001342490.1
NP_080320.1
XP_006498304.1
XP_006498305.1
XP_006498306.1
XP_006498308.1
XP_006498309.1
XP_006498310.1
XP_030107843.1
XP_030107844.1
XP_030107845.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355554.1 → NP_001342483.1  diphthine methyltransferase isoform b

    Status: VALIDATED

    Source sequence(s)
    AK153537, AL732585
    Conserved Domains (2) summary
    COG2319
    Location:38 → 207
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:29 → 65
    7WD40; WD40 repeat [structural motif]

  2. NM_001355556.1 → NP_001342485.1  diphthine methyltransferase isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4, 5, and 6, encodes isoform c.
    Source sequence(s)
    AL732585
    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  3. NM_001355557.1 → NP_001342486.1  diphthine methyltransferase isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3, 5, and 6, encodes isoform c.
    Source sequence(s)
    AL732585
    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  4. NM_001355558.1 → NP_001342487.1  diphthine methyltransferase isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
    Source sequence(s)
    AL732585
    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  5. NM_001355559.1 → NP_001342488.1  diphthine methyltransferase isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 3, 4, and 5, encodes isoform c.
    Source sequence(s)
    AL732585, BC086486
    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  6. NM_001355560.1 → NP_001342489.1  diphthine methyltransferase isoform d

    Status: VALIDATED

    Source sequence(s)
    AI430704, AL732585
    Conserved Domains (2) summary
    COG2319
    Location:16 → 134
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:46 → 82
    7WD40; WD40 repeat [structural motif]

  7. NM_001355561.1 → NP_001342490.1  diphthine methyltransferase isoform e

    Status: VALIDATED

    Source sequence(s)
    AL732585, CX221778
    Conserved Domains (2) summary
    COG2319
    Location:7 → 124
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:36 → 72
    7WD40; WD40 repeat [structural motif]

  8. NM_026044.4 → NP_080320.1  diphthine methyltransferase isoform a

    See identical proteins and their annotated locations for NP_080320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK013297, AK152000, AL732585
    Consensus CDS
    CCDS15743.1
    UniProtKB/Swiss-Prot
    A2AJ86, Q5RJV7, Q8BIT9, Q9CYU6
    Related
    ENSMUSP00000028351.4, ENSMUST00000028351.9
    Conserved Domains (3) summary
    COG2319
    Location:107 → 329
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:90 → 137
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:186 → 330
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    24852183..24862198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498241.2 → XP_006498304.1  diphthine methyltransferase isoform X1

    Conserved Domains (2) summary
    COG2319
    Location:86 → 255
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:77 → 113
    7WD40; WD40 repeat [structural motif]

  2. XM_006498242.4 → XP_006498305.1  diphthine methyltransferase isoform X2

    Conserved Domains (2) summary
    COG2319
    Location:16 → 238
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:60 → 96
    7WD40; WD40 repeat [structural motif]

  3. XM_006498245.2 → XP_006498308.1  diphthine methyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006498308.1

    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  4. XM_006498246.2 → XP_006498309.1  diphthine methyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006498309.1

    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  5. XM_030251983.1 → XP_030107843.1  diphthine methyltransferase isoform X4

    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  6. XM_006498243.4 → XP_006498306.1  diphthine methyltransferase isoform X3

    Conserved Domains (2) summary
    COG2319
    Location:41 → 210
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:32 → 68
    7WD40; WD40 repeat [structural motif]

  7. XM_030251984.1 → XP_030107844.1  diphthine methyltransferase isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:7 → 124
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:36 → 72
    7WD40; WD40 repeat [structural motif]

  8. XM_006498247.2 → XP_006498310.1  diphthine methyltransferase isoform X4

    See identical proteins and their annotated locations for XP_006498310.1

    UniProtKB/TrEMBL
    Q3U5K4
    Conserved Domains (2) summary
    COG2319
    Location:15 → 184
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:6 → 42
    7WD40; WD40 repeat [structural motif]

  9. XM_030251985.2 → XP_030107845.1  diphthine methyltransferase isoform X5

    Conserved Domains (2) summary
    COG2319
    Location:7 → 124
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:36 → 72
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CYU6.1 GenPept UniProtKB/Swiss-Prot:Q9CYU6

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