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Riok2 RIO kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 67045, updated on 2-Nov-2024

Summary

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Official Symbol
Riok2provided by MGI
Official Full Name
RIO kinase 2provided by MGI
Primary source
MGI:MGI:1914295
See related
Ensembl:ENSMUSG00000116564 AllianceGenome:MGI:1914295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2010110K24Rik; 2410085M17Rik
Summary
Predicted to enable protein kinase activity. Predicted to be involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Predicted to be located in cytoplasm. Predicted to be part of preribosome, small subunit precursor. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including adrenal gland; eye; genitourinary system; integumental system; and intestine. Orthologous to human RIOK2 (RIO kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 11.5), bladder adult (RPKM 8.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Riok2 in Genome Data Viewer
Location:
17 A3.2; 17 9.77 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (17594594..17615161)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17374332..17394899)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3184 Neighboring gene predicted gene, 36768 Neighboring gene STARR-positive B cell enhancer ABC_E7490 Neighboring gene predicted gene, 26873 Neighboring gene STARR-seq mESC enhancer starr_41952 Neighboring gene limb and CNS expressed 1 Neighboring gene STARR-seq mESC enhancer starr_41957 Neighboring gene STARR-seq mESC enhancer starr_41959 Neighboring gene predicted gene, 41537 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia. Messling JE, et al. Blood, 2022 Jan 13. PMID 34359076, Free PMC Article
  2. RIO-kinase 2 is essential for hematopoiesis. Messling JE, et al. PLoS One, 2024. PMID 38564577, Free PMC Article
  3. Blockade of IL-22 signaling reverses erythroid dysfunction in stress-induced anemias. Raundhal M, et al. Nat Immunol, 2021 Apr. PMID 33753942, Free PMC Article
  4. The RIO kinases: an atypical protein kinase family required for ribosome biogenesis and cell cycle progression. LaRonde-LeBlanc N, et al. Biochim Biophys Acta, 2005 Dec 30. PMID 16182620
  5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RIO-kinase 2 is essential for hematopoiesis.
    Title: RIO-kinase 2 is essential for hematopoiesis.
  2. Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.
    Title: Targeting RIOK2 ATPase activity leads to decreased protein synthesis and cell death in acute myeloid leukemia.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA IEA
Inferred from Electronic Annotation
more info
  
involved_in maturation of SSU-rRNA ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of rRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ribosomal small subunit export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ribosomal small subunit export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein autophosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic metaphase/anaphase transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ribosomal small subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of preribosome, small subunit precursor IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, small subunit precursor ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase RIO2
NP_080210.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025934.2 → NP_080210.1  serine/threonine-protein kinase RIO2

    See identical proteins and their annotated locations for NP_080210.1

    Status: VALIDATED

    Source sequence(s)
    AC154200, AI553565, AK008451, BY133202, BY710172
    Consensus CDS
    CCDS28417.1
    UniProtKB/Swiss-Prot
    Q91XF3, Q9CQS5
    UniProtKB/TrEMBL
    A0A338P7E9
    Related
    ENSMUSP00000024620.7, ENSMUST00000024620.8
    Conserved Domains (3) summary
    COG0478
    Location:8 → 308
    RIO2; RIO-like serine/threonine protein kinase fused to N-terminal HTH domain [Signal transduction mechanisms]
    cd05144
    Location:94 → 276
    RIO2_C; C-terminal catalytic domain of the atypical protein serine kinase, RIO2 kinase
    pfam09202
    Location:9 → 91
    Rio2_N; Rio2, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    17594594..17615161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQS5.1 GenPept UniProtKB/Swiss-Prot:Q9CQS5

Gene LinkOut

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