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Fank1 fibronectin type 3 and ankyrin repeat domains 1 [ Mus musculus (house mouse) ]

Gene ID: 66930, updated on 2-Nov-2024

Summary

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Official Symbol
Fank1provided by MGI
Official Full Name
fibronectin type 3 and ankyrin repeat domains 1provided by MGI
Primary source
MGI:MGI:1914180
See related
Ensembl:ENSMUSG00000053111 AllianceGenome:MGI:1914180
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FANK1S; 1700007B22Rik
Summary
Predicted to be involved in regulation of DNA-templated transcription and regulation of apoptotic process. Located in ciliary basal body. Is active in ciliary base. Is expressed in lung. Orthologous to human FANK1 (fibronectin type III and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 86.5) and CNS E18 (RPKM 2.7) See more
Orthologs
human all
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Genomic context

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See Fank1 in Genome Data Viewer
Location:
7 F3; 7 77.42 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (133378594..133483261)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (133776836..133881536)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10481 Neighboring gene uroporphyrinogen III synthase Neighboring gene STARR-seq mESC enhancer starr_20333 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene predicted gene 15483 Neighboring gene STARR-seq mESC enhancer starr_20336 Neighboring gene ADAM metallopeptidase domain 12 Neighboring gene STARR-seq mESC enhancer starr_20337 Neighboring gene predicted gene, 51500 Neighboring gene STARR-seq mESC enhancer starr_20338 Neighboring gene predicted gene, 39103

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice. Zhang J, et al. PeerJ, 2019. PMID 31086747, Free PMC Article
  2. Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis. Zheng Z, et al. Gene Expr Patterns, 2007 Aug. PMID 17604233
  3. Specific maternal transcripts in bovine oocytes and cleavaged embryos: identification with novel DDRT-PCR methods. Hwang KC, et al. Mol Reprod Dev, 2005 Jul. PMID 15803458
  4. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
  5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FANK1 may have a role in regulating gene expression in the transition from the meiotic phase to the haploid phase during spermatogenesis
    Title: Fank1 is a testis-specific gene encoding a nuclear protein exclusively expressed during the transition from the meiotic to the haploid phase of spermatogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary base IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
fibronectin type 3 and ankyrin repeat domains 1 protein
Names
GSG1
germ cell-specific 1
germ cell-specific gene 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418758.1 → NP_001405687.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127348, AC149611

  2. NM_025850.3 → NP_080126.1  fibronectin type 3 and ankyrin repeat domains 1 protein isoform 1

    See identical proteins and their annotated locations for NP_080126.1

    Status: VALIDATED

    Source sequence(s)
    AC127348, AC149611
    Consensus CDS
    CCDS21937.1
    UniProtKB/Swiss-Prot
    Q9CUA7, Q9DAM9
    UniProtKB/TrEMBL
    A0A1B0GSJ7
    Related
    ENSMUSP00000069013.6, ENSMUST00000065359.12
    Conserved Domains (6) summary
    cd00063
    Location:10 → 104
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00204
    Location:171 → 298
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00023
    Location:144 → 174
    Ank; Ankyrin repeat
    pfam12796
    Location:148 → 240
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:113 → 164
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:176 → 207
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    133378594..133483261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DAM9.1 GenPept UniProtKB/Swiss-Prot:Q9DAM9

Gene LinkOut

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