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Rras2 related RAS viral (r-ras) oncogene 2 [ Mus musculus (house mouse) ]

Gene ID: 66922, updated on 2-Nov-2024

Summary

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Official Symbol
Rras2provided by MGI
Official Full Name
related RAS viral (r-ras) oncogene 2provided by MGI
Primary source
MGI:MGI:1914172
See related
Ensembl:ENSMUSG00000055723 AllianceGenome:MGI:1914172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TC21; 2610016H24Rik
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Acts upstream of or within Ras protein signal transduction and positive regulation of Schwann cell migration. Predicted to be located in Golgi membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; cerebral cortex; lung; metanephros; and thymus primordium. Human ortholog(s) of this gene implicated in Noonan syndrome 12. Orthologous to human RRAS2 (RAS related 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 16.6), duodenum adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rras2 in Genome Data Viewer
Location:
7 F1; 7 59.29 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (113646017..113717016, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114046782..114117781, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5600 Neighboring gene spondin 1, (f-spondin) extracellular matrix protein Neighboring gene STARR-seq mESC enhancer starr_19921 Neighboring gene STARR-seq mESC enhancer starr_19922 Neighboring gene STARR-positive B cell enhancer ABC_E6588 Neighboring gene STARR-positive B cell enhancer ABC_E8937 Neighboring gene predicted gene, 51454 Neighboring gene STARR-positive B cell enhancer ABC_E9298 Neighboring gene predicted gene, 53365 Neighboring gene STARR-seq mESC enhancer starr_19925 Neighboring gene STARR-seq mESC enhancer starr_19926 Neighboring gene STARR-positive B cell enhancer ABC_E4966 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:121419678-121419787 Neighboring gene coatomer protein complex, subunit beta 1 Neighboring gene proteasome subunit alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System. Garcia-Martin G, et al. Int J Mol Sci, 2022 Jan 17. PMID 35055164, Free PMC Article
  2. Absence of R-Ras1 and R-Ras2 causes mitochondrial alterations that trigger axonal degeneration in a hypomyelinating disease model. Alcover-Sanchez B, et al. Glia, 2021 Mar. PMID 33010069
  3. Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Delgado P, et al. Nat Immunol, 2009 Aug. PMID 19561613
  4. T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis. Martínez-Martín N, et al. Immunity, 2011 Aug 26. PMID 21820331, Free PMC Article
  5. Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease. Larive RM, et al. Nat Commun, 2014 May 14. PMID 24826867

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
    Title: A hotspot mutation targeting the R-RAS2 GTPase acts as a potent oncogenic driver in a wide spectrum of tumors.
  2. Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
    Title: Overexpression of wild type RRAS2, without oncogenic mutations, drives chronic lymphocytic leukemia.
  3. R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
    Title: R-Ras1 and R-Ras2 Expression in Anatomical Regions and Cell Types of the Central Nervous System.
  4. An analysis of the TCR repertoire shows alterations that mostly affect the TCRalpha variable (TRAV) locus with specific VJ combinations and CDR3alpha sequences that are absent in Rras2(-/-) mice, suggesting their involvement in autoimmunity
    Title: RRAS2 shapes the TCR repertoire by setting the threshold for negative selection.
  5. Mice lacking R-Ras1 and/or R-Ras2 show a diminished oligodendrocytes population with a higher proportion of immature oligodendrocytes, explaining the observed hypomyelination
    Title: R-Ras1 and R-Ras2 Are Essential for Oligodendrocyte Differentiation and Survival for Correct Myelination in the Central Nervous System.
  6. SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.
    Title: SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.
  7. The RLIP76/R-Ras/ARNO complex localizes to recycling endosomes.RLIP76 is a linker protein connecting R-Ras to ARNO.
    Title: RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at recycling endosomes.
  8. R-Ras2 has a role in both primary breast tumorigenesis and the late metastatic steps of cancer cells in the lung parenchyma.
    Title: Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease.
  9. findings reveal R-Ras2 as a critical regulator of TGF-beta signaling in vivo.
    Title: In vivo regulation of TGF-β by R-Ras2 revealed through loss of the RasGAP protein NF1.
  10. Data indicate that RRas2(-/-) mice show no major alterations in viability, growth rates, cardiovascular parameters, or fertility.
    Title: The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of Schwann cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of Schwann cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein R-Ras2
Names
related RAS viral (r-ras) oncogene homolog 2
NP_080122.2
XP_017167728.1
XP_036009261.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025846.2 → NP_080122.2  ras-related protein R-Ras2

    See identical proteins and their annotated locations for NP_080122.2

    Status: VALIDATED

    Source sequence(s)
    AK003733, AK011419, AK078870, BX524069
    Consensus CDS
    CCDS21758.1
    UniProtKB/Swiss-Prot
    P62071, Q3TA79, Q8C5D1, Q9D0H6
    Related
    ENSMUSP00000069752.6, ENSMUST00000069449.7
    Conserved Domains (1) summary
    cd04145
    Location:13 → 176
    M_R_Ras_like; R-Ras2/TC21, M-Ras/R-Ras3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    113646017..113717016 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153368.1 → XP_036009261.1  ras-related protein R-Ras2 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_017312239.2 → XP_017167728.1  ras-related protein R-Ras2 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:1 → 99
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62071.1 GenPept UniProtKB/Swiss-Prot:P62071

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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