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Proz protein Z, vitamin K-dependent plasma glycoprotein [ Mus musculus (house mouse) ]

Gene ID: 66901, updated on 28-Oct-2024

Summary

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Official Symbol
Prozprovided by MGI
Official Full Name
protein Z, vitamin K-dependent plasma glycoproteinprovided by MGI
Primary source
MGI:MGI:1860488
See related
Ensembl:ENSMUSG00000031445 AllianceGenome:MGI:1860488
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1300015B06Rik
Summary
Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Located in extracellular region. Is expressed in liver and plasma. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in liver adult (RPKM 113.6), liver E18 (RPKM 53.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Proz in Genome Data Viewer
Location:
8 A1.1; 8 5.73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13110583..13126026)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13060584..13076026)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coagulation factor VII Neighboring gene coagulation factor X Neighboring gene PCI domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice. Butschkau A, et al. Int J Clin Exp Pathol, 2014. PMID 25337252, Free PMC Article
  2. Protein z exerts pro-angiogenic effects and upregulates CXCR4. Butschkau A, et al. PLoS One, 2014. PMID 25474349, Free PMC Article
  3. Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction. Butschkau A, et al. Crit Care Med, 2013 Dec. PMID 23963134, Free PMC Article
  4. Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response. Girard TJ, et al. J Thromb Haemost, 2013 Feb. PMID 23205927, Free PMC Article
  5. Mouse protein Z-dependent protease inhibitor cDNA. Zhang J, et al. Thromb Haemost, 2001 May. PMID 11372680

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PZ contributes to a reduced neointima formation after vascular injury, underlining the modulatory role of the coagulation cascade in vascular homeostasis.
    Title: Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice.
  2. Letter: protein Z is not a typical acute phase reactant.
    Title: Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
  3. PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype.
    Title: Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding TAS
Traceable Author Statement
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood coagulation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within blood coagulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vitamin K-dependent protein Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357219.1 → NP_001344148.1  vitamin K-dependent protein Z isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC127308
    Consensus CDS
    CCDS90373.1
    UniProtKB/TrEMBL
    Q8CI01
    Related
    ENSMUSP00000147733.2, ENSMUST00000211363.2
    Conserved Domains (4) summary
    smart00069
    Location:23 → 85
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:95 → 122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:136 → 165
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl27237
    Location:192 → 239
    Trypsin; Trypsin

  2. NM_001357220.1 → NP_001344149.1  vitamin K-dependent protein Z isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127308
    UniProtKB/TrEMBL
    Q05CL2
    Conserved Domains (3) summary
    cd00054
    Location:25 → 52
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00089
    Location:122 → 270
    Trypsin; Trypsin
    pfam14670
    Location:66 → 95
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. NM_025834.4 → NP_080110.1  vitamin K-dependent protein Z isoform 1 precursor

    See identical proteins and their annotated locations for NP_080110.1

    Status: VALIDATED

    Source sequence(s)
    AC127308, AK005011, AK008819
    Consensus CDS
    CCDS22105.1
    UniProtKB/Swiss-Prot
    Q9CQW3
    Related
    ENSMUSP00000033822.3, ENSMUST00000033822.4
    Conserved Domains (5) summary
    smart00069
    Location:23 → 85
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:95 → 122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00089
    Location:192 → 340
    Trypsin; Trypsin
    pfam14670
    Location:136 → 165
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl21584
    Location:192 → 397
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    13110583..13126026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508859.5 → XP_006508922.1  vitamin K-dependent protein Z isoform X2

    Conserved Domains (3) summary
    smart00069
    Location:23 → 85
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:95 → 122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:136 → 165
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_006508858.4 → XP_006508921.1  vitamin K-dependent protein Z isoform X1

    Conserved Domains (3) summary
    smart00069
    Location:23 → 85
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:95 → 122
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam14670
    Location:136 → 165
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQW3.1 GenPept UniProtKB/Swiss-Prot:Q9CQW3

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