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Tanc1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 [ Mus musculus (house mouse) ]

Gene ID: 66860, updated on 2-Nov-2024

Summary

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Official Symbol
Tanc1provided by MGI
Official Full Name
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by MGI
Primary source
MGI:MGI:1914110
See related
Ensembl:ENSMUSG00000035168 AllianceGenome:MGI:1914110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tanc; mKIAA1728; 1200003E16Rik
Summary
Acts upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Located in axon terminus; dendrite; and neuronal cell body. Is expressed in mandible; maxilla; metanephros; olfactory cortex ventricular layer; and telencephalon ventricular layer. Orthologous to human TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 4.4), lung adult (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tanc1 in Genome Data Viewer
Location:
2 C1.1; 2 33.93 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (59442167..59676557)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (59611821..59846213)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm717 Neighboring gene mitochondrial ribosomal protein S18B pseudogene Neighboring gene STARR-seq mESC enhancer starr_04580 Neighboring gene STARR-seq mESC enhancer starr_04583 Neighboring gene predicted gene, 53240 Neighboring gene STARR-seq mESC enhancer starr_04592 Neighboring gene VISTA enhancer mm282 Neighboring gene WD repeat, SAM and U-box domain containing 1 Neighboring gene predicted gene, 52554 Neighboring gene STARR-seq mESC enhancer starr_04594 Neighboring gene bromodomain adjacent to zinc finger domain, 2B Neighboring gene STARR-seq mESC enhancer starr_04597 Neighboring gene STARR-seq mESC enhancer starr_04598 Neighboring gene STARR-seq mESC enhancer starr_04600 Neighboring gene predicted gene 13572

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation. Yang Q, et al. Biochim Biophys Acta Mol Cell Res, 2024 Feb. PMID 38092135
  2. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. Avirneni-Vadlamudi U, et al. J Clin Invest, 2012 Jan. PMID 22182840, Free PMC Article
  3. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. Han S, et al. J Neurosci, 2010 Nov 10. PMID 21068316, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2002 Oct 31. PMID 12465718
  5. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
    Title: Tanc1/2 TPR domain interacts with Myo18a C-terminus and undergoes liquid-liquid phase separation.
  2. These results suggest that TANC1 is important for dendritic spine maintenance and spatial memory
    Title: Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density, intracellular component ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein TANC1
Names
TPR domain, ankyrin-repeat and coiled-coil-containing protein
tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290659.1 → NP_001277588.1  protein TANC1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a. The 5' UTR of this variant is incomplete due to a lack of full-length transcript support and splice pattern ambiguity in the upstream region.
    Source sequence(s)
    AK031162, AK079966, BC079914, BY753173, CX769146
    Consensus CDS
    CCDS71057.1
    UniProtKB/TrEMBL
    B9EJ77, E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:896 → 1208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1275 → 1406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1282 → 1307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1135 → 1165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1082 → 1306
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_198294.3 → NP_938036.2  protein TANC1 isoform a

    See identical proteins and their annotated locations for NP_938036.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). The 5'-most non-coding exon of this variant is inferred based on partial transcript alignments.
    Source sequence(s)
    AK031162, AK079966, BC079914, BY753173, CX769146
    Consensus CDS
    CCDS16054.1
    UniProtKB/Swiss-Prot
    A2AUL4, A2AUL6, Q0VGY8, Q80VD2, Q8C0Q6
    UniProtKB/TrEMBL
    B9EJ77
    Related
    ENSMUSP00000036003.5, ENSMUST00000037526.11
    Conserved Domains (5) summary
    PHA03095
    Location:903 → 1215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1282 → 1413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1289 → 1314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1142 → 1172
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1089 → 1313
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    59442167..59676557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319203.3 → XP_017174692.1  protein TANC1 isoform X1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_030251967.1 → XP_030107827.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    B9EJ77, E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:896 → 1208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1275 → 1406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1282 → 1307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1135 → 1165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1082 → 1306
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_017319205.3 → XP_017174694.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    B9EJ77, E9QAF9
    Related
    ENSMUSP00000108187.2, ENSMUST00000112568.8
    Conserved Domains (5) summary
    PHA03095
    Location:896 → 1208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1275 → 1406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1282 → 1307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1135 → 1165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1082 → 1306
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036162490.1 → XP_036018383.1  protein TANC1 isoform X3

    UniProtKB/Swiss-Prot
    A2AUL4, A2AUL6, Q0VGY8, Q80VD2, Q8C0Q6
    UniProtKB/TrEMBL
    B9EJ77
    Related
    ENSMUSP00000123345.3, ENSMUST00000139863.3
    Conserved Domains (5) summary
    PHA03095
    Location:903 → 1215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1282 → 1413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1289 → 1314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1142 → 1172
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1089 → 1313
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_006500034.5 → XP_006500097.1  protein TANC1 isoform X1

    See identical proteins and their annotated locations for XP_006500097.1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_017319200.3 → XP_017174689.1  protein TANC1 isoform X1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  7. XM_030251966.2 → XP_030107826.1  protein TANC1 isoform X1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  8. XM_036162489.1 → XP_036018382.1  protein TANC1 isoform X3

    UniProtKB/Swiss-Prot
    A2AUL4, A2AUL6, Q0VGY8, Q80VD2, Q8C0Q6
    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (5) summary
    PHA03095
    Location:903 → 1215
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1282 → 1413
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1289 → 1314
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1142 → 1172
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1089 → 1313
    Ank_2; Ankyrin repeats (3 copies)

  9. XM_036162492.1 → XP_036018385.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    B9EJ77, E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:896 → 1208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1275 → 1406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1282 → 1307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1135 → 1165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1082 → 1306
    Ank_2; Ankyrin repeats (3 copies)

  10. XM_006500037.5 → XP_006500100.1  protein TANC1 isoform X2

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:914 → 1226
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1293 → 1424
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1300 → 1325
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1153 → 1183
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1503 → 1795
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1100 → 1324
    Ank_2; Ankyrin repeats (3 copies)

  11. XM_017319204.3 → XP_017174693.1  protein TANC1 isoform X1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  12. XM_036162491.1 → XP_036018384.1  protein TANC1 isoform X4

    UniProtKB/TrEMBL
    B9EJ77, E9QAF9
    Conserved Domains (5) summary
    PHA03095
    Location:896 → 1208
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1275 → 1406
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1282 → 1307
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1135 → 1165
    ANK; ANK repeat [structural motif]
    cl39094
    Location:1082 → 1306
    Ank_2; Ankyrin repeats (3 copies)

  13. XM_017319202.3 → XP_017174691.1  protein TANC1 isoform X1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  14. XM_006500036.5 → XP_006500099.1  protein TANC1 isoform X1

    See identical proteins and their annotated locations for XP_006500099.1

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:921 → 1233
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1300 → 1431
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1307 → 1332
    TPR; TPR repeat [structural motif]
    sd00045
    Location:1160 → 1190
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1510 → 1802
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:1107 → 1331
    Ank_2; Ankyrin repeats (3 copies)

  15. XM_006500039.3 → XP_006500102.1  protein TANC1 isoform X5

    UniProtKB/TrEMBL
    B9EJ77
    Conserved Domains (6) summary
    PHA03095
    Location:703 → 1015
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:1082 → 1213
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:1089 → 1114
    TPR; TPR repeat [structural motif]
    sd00045
    Location:942 → 972
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1292 → 1584
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:889 → 1113
    Ank_2; Ankyrin repeats (3 copies)

  16. XM_006500040.5 → XP_006500103.1  protein TANC1 isoform X6

    UniProtKB/TrEMBL
    Q8CHA0
    Conserved Domains (6) summary
    PHA03095
    Location:599 → 911
    PHA03095; ankyrin-like protein; Provisional
    COG0457
    Location:978 → 1109
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:985 → 1010
    TPR; TPR repeat [structural motif]
    sd00045
    Location:838 → 868
    ANK; ANK repeat [structural motif]
    pfam09606
    Location:1188 → 1480
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    cl39094
    Location:785 → 1009
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VGY8.2 GenPept UniProtKB/Swiss-Prot:Q0VGY8

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