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Trim35 tripartite motif-containing 35 [ Mus musculus (house mouse) ]

Gene ID: 66854, updated on 2-Nov-2024

Summary

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Official Symbol
Trim35provided by MGI
Official Full Name
tripartite motif-containing 35provided by MGI
Primary source
MGI:MGI:1914104
See related
Ensembl:ENSMUSG00000022043 AllianceGenome:MGI:1914104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NC8; HLS5; Mair; mKIAA1098; 0710005M05Rik; A430106H13Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within negative regulation of cell population proliferation and positive regulation of myeloid cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; lung; and sensory organ. Orthologous to human TRIM35 (tripartite motif containing 35). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 102.9), adrenal adult (RPKM 97.9) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Trim35 in Genome Data Viewer
Location:
14 D1; 14 34.44 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (66534474..66548873)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (66297025..66311424)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene PTK2 protein tyrosine kinase 2 beta Neighboring gene STARR-positive B cell enhancer ABC_E7326 Neighboring gene STARR-seq mESC enhancer starr_36992 Neighboring gene predicted gene, 52098 Neighboring gene STARR-positive B cell enhancer ABC_E3121 Neighboring gene STARR-seq mESC enhancer starr_36993 Neighboring gene STARR-seq mESC enhancer starr_36994 Neighboring gene predicted gene, 52099 Neighboring gene STARR-positive B cell enhancer ABC_E7327 Neighboring gene STARR-seq mESC enhancer starr_36995 Neighboring gene RIKEN cDNA 1700001G11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:66915655-66915915 Neighboring gene STARR-positive B cell enhancer ABC_E8565 Neighboring gene predicted gene, 41183 Neighboring gene stathmin-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure. Lorenzana-Carrillo MA, et al. Circ Res, 2024 Jul 5. PMID 38860363
  2. Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model. Chen Y, et al. Histol Histopathol, 2020 Dec. PMID 32955098
  3. Hls5 regulated erythroid differentiation by modulating GATA-1 activity. Endersby R, et al. Blood, 2008 Feb 15. PMID 18063753
  4. Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation. Liu M, et al. Chin Med J (Engl), 2010 May 5. PMID 20529561
  5. HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor. Lalonde JP, et al. J Biol Chem, 2004 Feb 27. PMID 14662771

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.
    Title: TRIM35 triggers cardiac remodeling by regulating SLC7A5-mediated amino acid transport and mTORC1 activation in fibroblasts.
  2. TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.
    Title: TRIM35 Monoubiquitinates H2B in Cardiac Cells, Implications for Heart Failure.
  3. The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
    Title: The inhibition of TRIM35-mediated TIGAR ubiquitination enhances mitochondrial fusion and alleviates renal ischemia-reperfusion injury.
  4. Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model.
    Title: Tripartite motif-containing 35 (TRIM35) is up-regulated in UUO-induced renal fibrosis animal model.
  5. TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
    Title: TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2.
  6. Data suggest that Trim35 (tripartite motif-containing 35) down-regulates type I interferon production in dendritic cells via toll-like receptors 7/9 and down-regulates stability of Irf7 (interferon regulatory factor 7) via ubiquitination/proteasomes.
    Title: TRIM35 negatively regulates TLR7- and TLR9-mediated type I interferon production by targeting IRF7.
  7. C/EBPbeta may regulate preadipocyte proliferation through activation of banp and trim35.
    Title: Identification and validation of novel C/EBPbeta-regulated genes in preadipocyte proliferation.
  8. isolated from monocytoid variant, but not parental J2E erythroleukemia cells; expressed in wide range of adult tissues; at different stages of embryogenesis, Hls5 was detected in the branchial arches, spinal cord, dorsal root ganglia, limb buds, and brain
    Title: HLS5, a novel RBCC (ring finger, B box, coiled-coil) family member isolated from a hemopoietic lineage switch, is a candidate tumor suppressor.
  9. a novel RING-B-box-coiled-coil (RBCC) protein that consists of an N-terminal RING finger, followed by a B-box zinc finger, a coiled-coil domain, and a B30.2 domain; cloning and characterization
    Title: Cloning and characterization of a novel RING-B-box-coiled-coil protein with apoptotic function.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5)  1 citation
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase TRIM35
Names
hemopoietic lineage switch protein 5
macrophage-derived apoptosis-inducing RBCC protein
protein Nc8
tripartite motif-containing protein 35
NP_084255.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_029979.3 → NP_084255.2  E3 ubiquitin-protein ligase TRIM35

    See identical proteins and their annotated locations for NP_084255.2

    Status: VALIDATED

    Source sequence(s)
    AC140329, AF145374
    Consensus CDS
    CCDS27221.2
    UniProtKB/Swiss-Prot
    A6H681, Q6ZPY0, Q7TQL7, Q810V7, Q8BVY9, Q8C006, Q8VID4, Q9CW74, Q9D208
    UniProtKB/TrEMBL
    A0A0R4J031
    Related
    ENSMUSP00000022623.7, ENSMUST00000022623.13
    Conserved Domains (4) summary
    cd00021
    Location:114 → 152
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam13863
    Location:166 → 262
    DUF4200; Domain of unknown function (DUF4200)
    cl02614
    Location:318 → 504
    SPRY; SPRY domain
    cl17238
    Location:33 → 77
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    66534474..66548873
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C006.2 GenPept UniProtKB/Swiss-Prot:Q8C006

Gene LinkOut

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