Hint3 histidine triad nucleotide binding protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hint3provided by MGI
Official Full Name: histidine triad nucleotide binding protein 3provided by MGI
Primary source: MGI:MGI:1914097
See related: Ensembl:ENSMUSG00000019791 AllianceGenome:MGI:1914097
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HINT4; HINT-3; HINT-4; 0610010I17Rik
Summary: Predicted to enable adenosine 5'-monophosphoramidase activity and identical protein binding activity. Predicted to be located in cytoplasm and nucleus. Is expressed in embryo; liver; lung; metanephros; and spleen. Orthologous to human HINT3 (histidine triad nucleotide binding protein 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 4.5), heart adult (RPKM 4.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A4; 10 17.1 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (30479191..30499526, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (30603195..30623530, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables adenosine 5'-monophosphoramidase activity	ISO Inferred from Sequence Orthology more info
enables adenosine 5'-monophosphoramidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: adenosine 5'-monophosphoramidase HINT3

Names: histidine triad protein 4

NP_080074.1

EC 3.-.-.-

XP_006512886.1

EC 3.-.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025798.3 → NP_080074.1 adenosine 5'-monophosphoramidase HINT3

See identical proteins and their annotated locations for NP_080074.1

Status: PROVISIONAL

Source sequence(s)

AK027974

Consensus CDS

CCDS23764.1

UniProtKB/Swiss-Prot

Q9CPS6

UniProtKB/TrEMBL

F8WH96

Related

ENSMUSP00000125552.2, ENSMUST00000161074.8

Conserved Domains (1) summary

cd01278
Location:30 → 133

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

30479191..30499526 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512823.3 → XP_006512886.1 adenosine 5'-monophosphoramidase HINT3 isoform X1

Conserved Domains (1) summary

cd01278
Location:30 → 168

aprataxin_related; aprataxin related: Aprataxin, a HINT family hydrolase is mutated in ataxia oculomotor apraxia syndrome. All the members of this subgroup have the conserved HxHxHxx (where x is a hydrophobic residue) signature motif. Members of this subgroup are ...