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Sirpb1b signal-regulatory protein beta 1B [ Mus musculus (house mouse) ]

Gene ID: 668101, updated on 2-Nov-2024

Summary

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Official Symbol
Sirpb1bprovided by MGI
Official Full Name
signal-regulatory protein beta 1Bprovided by MGI
Primary source
MGI:MGI:3779828
See related
Ensembl:ENSMUSG00000095028 AllianceGenome:MGI:3779828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in positive regulation of T cell activation and positive regulation of phagocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including SIRPB1 (signal regulatory protein beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 2.2), lung adult (RPKM 1.6) and 7 other tissues See more
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Genomic context

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See Sirpb1b in Genome Data Viewer
Location:
3 A1; 3 3.67 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (15560814..15640127, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (15495754..15575067, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07026 Neighboring gene signal regulatory protein delta Neighboring gene signal-regulatory protein beta 1A Neighboring gene zinc finger protein 947 pseudogene Neighboring gene predicted gene, 54192 Neighboring gene signal-regulatory protein beta 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
  5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
signal-regulatory protein beta 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173460.1 → NP_001166931.1  signal-regulatory protein beta 1B

    See identical proteins and their annotated locations for NP_001166931.1

    Status: VALIDATED

    Source sequence(s)
    AC161359, AC171624
    Consensus CDS
    CCDS50867.1
    UniProtKB/TrEMBL
    A0A0A6YXN8, Q3U390
    Related
    ENSMUSP00000088869.5, ENSMUST00000091319.7
    Conserved Domains (4) summary
    cd00098
    Location:247 → 341
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:42 → 142
    IG_like; Immunoglobulin like
    pfam07686
    Location:45 → 143
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:141 → 252
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    15560814..15640127 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319689.1 → XP_017175178.1  signal-regulatory protein beta 1B isoform X2

    UniProtKB/TrEMBL
    A0A0A6YXN8
    Conserved Domains (3) summary
    cd05772
    Location:143 → 246
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:248 → 350
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:30 → 141
    Ig; Immunoglobulin domain

  2. XM_006530083.1 → XP_006530146.1  signal-regulatory protein beta 1B isoform X1

    UniProtKB/TrEMBL
    A0A0A6YXN8
    Conserved Domains (3) summary
    cd05772
    Location:145 → 248
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:250 → 352
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:32 → 143
    Ig; Immunoglobulin domain

  3. XM_006530085.3 → XP_006530148.1  signal-regulatory protein beta 1B isoform X3

    Conserved Domains (2) summary
    cd05772
    Location:2 → 99
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:101 → 203
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3

  4. XM_017319690.1 → XP_017175179.1  signal-regulatory protein beta 1B isoform X3

    Conserved Domains (2) summary
    cd05772
    Location:2 → 99
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:101 → 203
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
Nucleotide Protein Strain
Heading Accession and Version

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