U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Krt20 keratin 20 [ Mus musculus (house mouse) ]

Gene ID: 66809, updated on 28-Oct-2024

Summary

Official Symbol
Krt20provided by MGI
Official Full Name
keratin 20provided by MGI
Primary source
MGI:MGI:1914059
See related
Ensembl:ENSMUSG00000035775 AllianceGenome:MGI:1914059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
K20; Ck20; Ck-20; Krt21; 9030623C06Rik
Summary
This gene encodes a member of the keratin protein family and is found within a cluster of cytokeratin genes on chromosome 11. Keratins are cytoskeletal proteins that are preferentially expressed in epithelial cells. The encoded protein may help maintain intermediate filament organization in intestinal epithelium. Phosphorylation of this protein may also influence mucin secretion in the small intestine. [provided by RefSeq, Dec 2015]
Expression
Biased expression in large intestine adult (RPKM 276.4), small intestine adult (RPKM 251.1) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Krt20 in Genome Data Viewer
Location:
11 D; 11 62.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (99319211..99328979, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (99428385..99438153, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247019-99247320 Neighboring gene STARR-positive B cell enhancer mm9_chr11:99247331-99247631 Neighboring gene keratin 10 Neighboring gene RIKEN cDNA A830036E02 gene Neighboring gene keratin 12 Neighboring gene keratin 23 Neighboring gene keratin 39

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intermediate filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intermediate filament organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein secretion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 20
Names
cytokeratin 20

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023256.2NP_075745.1  keratin, type I cytoskeletal 20

    See identical proteins and their annotated locations for NP_075745.1

    Status: REVIEWED

    Source sequence(s)
    AK018567, AL591165
    Consensus CDS
    CCDS25381.1
    UniProtKB/Swiss-Prot
    Q6PG82, Q9D312
    Related
    ENSMUSP00000017743.3, ENSMUST00000017743.3
    Conserved Domains (1) summary
    pfam00038
    Location:76385
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    99319211..99328979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)