U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

lytA N-acetylmuramoyl-L-alanine amidase LytA [ Streptococcus pneumoniae ]

Gene ID: 66807010, discontinued on 23-Aug-2024
  • This record was discontinued.

Summary

Go to the top of the page Help
Gene symbol
lytA
Gene description
N-acetylmuramoyl-L-alanine amidase LytA
Locus tag
SPNHU17_RS09250
Gene type
protein coding
Organism
Streptococcus pneumoniae (strain: Hu17, nat-host: Homo sapiens)
Lineage
Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
Old locus tag
SPNHU17_01979
NEW
Try the new Gene table
Try the new Transcript table

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NZ_CP020549.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Key role of amino acid residues in the dimerization and catalytic activation of the autolysin LytA, an important virulence factor in Streptococcus pneumoniae. Romero P, et al. J Biol Chem, 2007 Jun 15. PMID 17439951
  2. Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages. Cao S, et al. Mol Immunol, 2021 Dec. PMID 34673375
  3. Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC. Eldholm V, et al. Microbiology (Reading), 2009 Jul. PMID 19389766
  4. The Emergence of Invasive Streptococcus pneumoniae Serotype 24F in Lebanon: Complete Genome Sequencing Reveals High Virulence and Antimicrobial Resistance Characteristics. Reslan L, et al. Front Microbiol, 2021. PMID 33746930, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.
    Title: Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.
Submit: New GeneRIF Correction

General protein information

Go to the top of the page Help
Preferred Names
N-acetylmuramoyl-L-alanine amidase LytA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NZ_CP020549.1 Reference assembly

    Range
    1836706..1837662 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_000405234.1 MULTISPECIES: N-acetylmuramoyl-L-alanine amidase LytA [Streptococcus]

    See identical proteins and their annotated locations for WP_000405234.1

    Conserved Domains (1) summary
    COG5263
    Location:1 → 316
    COG5263; Glucan-binding domain (YG repeat) [Carbohydrate transport and metabolism]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.