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Atg10 autophagy related 10 [ Mus musculus (house mouse) ]

Gene ID: 66795, updated on 2-Nov-2024

Summary

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Official Symbol
Atg10provided by MGI
Official Full Name
autophagy related 10provided by MGI
Primary source
MGI:MGI:1914045
See related
Ensembl:ENSMUSG00000021619 AllianceGenome:MGI:1914045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
APG10; Agp10; Apg10l; Apg10p; Atg10l; mAPG10; 5330424L23Rik; 5430428K15Rik
Summary
Enables Atg12 conjugating enzyme activity. Acts upstream of or within positive regulation of protein modification process and protein lipidation. Predicted to be located in cytosol. Orthologous to human ATG10 (autophagy related 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 1.2), heart adult (RPKM 0.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Atg10 in Genome Data Viewer
Location:
13 C3; 13 46.46 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (91083467..91372189, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (90935348..91224725, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+ transporting, lysosomal accessory protein 1-like Neighboring gene STARR-positive B cell enhancer ABC_E3091 Neighboring gene ribosomal protein S23 Neighboring gene STARR-seq mESC enhancer starr_35246 Neighboring gene STARR-seq mESC enhancer starr_35249 Neighboring gene STARR-seq mESC enhancer starr_35250 Neighboring gene 40S ribosomal protein S14 pseudogene Neighboring gene predicted gene, 41014 Neighboring gene heterogeneous nuclear ribonucleoprotein K pseudogene Neighboring gene RIKEN cDNA A830009L08 gene Neighboring gene STARR-seq mESC enhancer starr_35251 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:91510584-91510802

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. Mizushima N, et al. FEBS Lett, 2002 Dec 18. PMID 12482611
  2. The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. Nemoto T, et al. J Biol Chem, 2003 Oct 10. PMID 12890687
  3. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Radoshevich L, et al. Cell, 2010 Aug 20. PMID 20723759, Free PMC Article
  4. Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival. Li H, et al. Cell Rep, 2022 Oct 4. PMID 36198274
  5. Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta. Thuret S, et al. Mol Cell Neurosci, 2004 Mar. PMID 15033168

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The isolated mouse APG10 gene product interacts with mammalian Apg12p dependent on mammalian Apg7p (E1-like enzyme), and facilitates Apg12p conjugation.
    Title: The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.
  2. APG10 has a role in mediating the conjugation of APG12 with APG5
    Title: Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Atg12 conjugating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Atg12 conjugating enzyme activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Atg12 conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables Atg12 transferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables Atg12 transferase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ER overload response ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in mitophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of protein modification process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein lipidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein modification by small protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein modification by small protein conjugation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
ubiquitin-like-conjugating enzyme ATG10
Names
autophagy-related protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001404917.1 → NP_001391846.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029

  2. NM_001404918.1 → NP_001391847.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029

  3. NM_001404919.1 → NP_001391848.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029

  4. NM_001404920.1 → NP_001391849.1  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    UniProtKB/TrEMBL
    A0A0R4J029

  5. NM_001404921.1 → NP_001391850.1  ubiquitin-like-conjugating enzyme ATG10 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980

  6. NM_001404922.1 → NP_001391851.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980

  7. NM_001404923.1 → NP_001391852.1  ubiquitin-like-conjugating enzyme ATG10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980

  8. NM_001404925.1 → NP_001391854.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980

  9. NM_001404926.1 → NP_001391855.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980

  10. NM_001404927.1 → NP_001391856.1  ubiquitin-like-conjugating enzyme ATG10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980

  11. NM_001404928.1 → NP_001391857.1  ubiquitin-like-conjugating enzyme ATG10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC160980

  12. NM_025770.4 → NP_080046.3  ubiquitin-like-conjugating enzyme ATG10 isoform 1

    See identical proteins and their annotated locations for NP_080046.3

    Status: VALIDATED

    Source sequence(s)
    AC108947, AC134461, AC160980
    Consensus CDS
    CCDS26675.1
    UniProtKB/Swiss-Prot
    Q8BPA9, Q8R1P4, Q9D3J7
    UniProtKB/TrEMBL
    A0A0R4J029
    Related
    ENSMUSP00000022119.5, ENSMUST00000022119.6
    Conserved Domains (1) summary
    pfam03987
    Location:95 → 162
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    91083467..91372189 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244552.4 → XP_011242854.1  ubiquitin-like-conjugating enzyme ATG10 isoform X3

    Conserved Domains (1) summary
    pfam03987
    Location:54 → 121
    Autophagy_act_C; Autophagocytosis associated protein, active-site domain

RNA

  1. XR_873450.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R1P4.1 GenPept UniProtKB/Swiss-Prot:Q8R1P4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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