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Erlec1 endoplasmic reticulum lectin 1 [ Mus musculus (house mouse) ]

Gene ID: 66753, updated on 2-Nov-2024

Summary

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Official Symbol
Erlec1provided by MGI
Official Full Name
endoplasmic reticulum lectin 1provided by MGI
Primary source
MGI:MGI:1914003
See related
Ensembl:ENSMUSG00000020311 AllianceGenome:MGI:1914003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4933407N01Rik
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in negative regulation of retrograde protein transport, ER to cytosol and retrograde protein transport, ER to cytosol. Predicted to be active in endoplasmic reticulum lumen. Is expressed in mandible; maxilla; orbito-sphenoid; and rib. Orthologous to human ERLEC1 (endoplasmic reticulum lectin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in cerebellum adult (RPKM 3.4), bladder adult (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Erlec1 in Genome Data Viewer
Location:
11 A4; 11 18.18 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (30812794..30904385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (30862794..30954386, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29068 Neighboring gene predicted gene 12100 Neighboring gene STARR-seq mESC enhancer starr_29070 Neighboring gene proteasome (prosome, macropain) activator subunit 4 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene G protein-coupled receptor 75 Neighboring gene PDZ and LIM domain protein 1 pseudogene Neighboring gene ankyrin repeat and SOCS box-containing 3 Neighboring gene ChaC, cation transport regulator 2 Neighboring gene GPN-loop GTPase 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. Cruciat CM, et al. J Biol Chem, 2006 May 5. PMID 16531414
  2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Erlectin functions in N-glycan recognition in the endoplasmic reticulum and may regulate glycoprotein traffic
    Title: The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
enables unfolded protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in ERAD pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in endoplasmic reticulum unfolded protein response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of retrograde protein transport, ER to cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde protein transport, ER to cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
endoplasmic reticulum lectin 1
Names
ER lectin
erlectin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025745.3 → NP_080021.3  endoplasmic reticulum lectin 1 precursor

    See identical proteins and their annotated locations for NP_080021.3

    Status: VALIDATED

    Source sequence(s)
    AK133874, AL662891
    Consensus CDS
    CCDS24509.1
    UniProtKB/Swiss-Prot
    Q3UZF3, Q8BVN6, Q8VEH8
    UniProtKB/TrEMBL
    Q9CWA6
    Related
    ENSMUSP00000072929.8, ENSMUST00000073192.14
    Conserved Domains (2) summary
    pfam07915
    Location:342 → 421
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:206 → 250
    PRKCSH; Glucosidase II beta subunit-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    30812794..30904385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243744.3 → XP_011242046.1  endoplasmic reticulum lectin 1 isoform X3

    UniProtKB/TrEMBL
    Q9CWA6
    Conserved Domains (2) summary
    pfam07915
    Location:342 → 421
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:206 → 250
    PRKCSH; Glucosidase II beta subunit-like protein

  2. XM_011243743.4 → XP_011242045.1  endoplasmic reticulum lectin 1 isoform X2

    UniProtKB/TrEMBL
    Q9CWA6
    Conserved Domains (2) summary
    pfam07915
    Location:342 → 421
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:206 → 250
    PRKCSH; Glucosidase II beta subunit-like protein

  3. XM_030246233.2 → XP_030102093.1  endoplasmic reticulum lectin 1 isoform X1

    UniProtKB/TrEMBL
    Q9CWA6
    Conserved Domains (2) summary
    pfam07915
    Location:342 → 421
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:206 → 250
    PRKCSH; Glucosidase II beta subunit-like protein

  4. XM_006514781.4 → XP_006514844.1  endoplasmic reticulum lectin 1 isoform X4

    UniProtKB/TrEMBL
    Q9CWA6
    Conserved Domains (2) summary
    pfam07915
    Location:342 → 421
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:206 → 250
    PRKCSH; Glucosidase II beta subunit-like protein

  5. XM_030246234.2 → XP_030102094.1  endoplasmic reticulum lectin 1 isoform X6

    Conserved Domains (2) summary
    pfam07915
    Location:158 → 237
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:22 → 66
    PRKCSH; Glucosidase II beta subunit-like protein

  6. XM_006514782.5 → XP_006514845.1  endoplasmic reticulum lectin 1 isoform X5

    UniProtKB/TrEMBL
    Q9CWA6
    Conserved Domains (2) summary
    pfam07915
    Location:342 → 421
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:206 → 250
    PRKCSH; Glucosidase II beta subunit-like protein

  7. XM_030246235.2 → XP_030102095.1  endoplasmic reticulum lectin 1 isoform X7

    Conserved Domains (2) summary
    pfam07915
    Location:158 → 237
    PRKCSH; Glucosidase II beta subunit-like protein
    cl06793
    Location:22 → 66
    PRKCSH; Glucosidase II beta subunit-like protein

RNA

  1. XR_004937005.1 RNA Sequence

  2. XR_003949491.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8VEH8.1 GenPept UniProtKB/Swiss-Prot:Q8VEH8

Gene LinkOut

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