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Eef1d eukaryotic translation elongation factor 1 delta [ Mus musculus (house mouse) ]

Gene ID: 66656, updated on 2-Nov-2024

Summary

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Official Symbol
Eef1dprovided by MGI
Official Full Name
eukaryotic translation elongation factor 1 deltaprovided by MGI
Primary source
MGI:MGI:1913906
See related
Ensembl:ENSMUSG00000055762 AllianceGenome:MGI:1913906
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EF-1-delta
Summary
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; guanyl-nucleotide exchange factor activity; and heat shock protein binding activity. Predicted to be involved in several processes, including cellular response to heat; cellular response to ionizing radiation; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is active in glutamatergic synapse. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human EEF1D (eukaryotic translation elongation factor 1 delta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 124.2), liver E14 (RPKM 58.1) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Eef1d in Genome Data Viewer
Location:
15 D3; 15 35.05 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75766643..75781425, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75894796..75909784, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 6 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice. Kaitsuka T, et al. Front Mol Neurosci, 2018. PMID 30333725, Free PMC Article
  2. Oncogenic potential of mouse translation elongation factor-1 delta, a novel cadmium-responsive proto-oncogene. Joseph P, et al. J Biol Chem, 2002 Feb 22. PMID 11711542
  3. Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis. Joseph P, et al. Mol Cell Biochem, 2004 Jan. PMID 14971650
  4. Quantitative analysis of synaptic phosphorylation and protein expression. Trinidad JC, et al. Mol Cell Proteomics, 2008 Apr. PMID 18056256
  5. Transformation of eEF1Bδ into heat-shock response transcription factor by alternative splicing. Kaitsuka T, et al. EMBO Rep, 2011 Jul 1. PMID 21597468, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the up-regulation of expression of TEF-1delta is a novel molecular mechanism responsible, at least in part, for cadmium carcinogenesis
    Title: Up-regulation of expression of translation factors--a novel molecular mechanism for cadmium carcinogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 5730529A16Rik, 1700026P12Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of eukaryotic translation elongation factor 1 complex IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
elongation factor 1-delta
Names
eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285429.2 → NP_001272358.1  elongation factor 1-delta isoform b

    See identical proteins and their annotated locations for NP_001272358.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27554.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    Q80T06
    Conserved Domains (1) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  2. NM_001285430.2 → NP_001272359.1  elongation factor 1-delta isoform b

    See identical proteins and their annotated locations for NP_001272359.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27554.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    Q80T06
    Related
    ENSMUSP00000023235.7, ENSMUST00000023235.13
    Conserved Domains (1) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  3. NM_001285431.2 → NP_001272360.1  elongation factor 1-delta isoform c

    See identical proteins and their annotated locations for NP_001272360.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS70638.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    A0A0R4J1L2
    Conserved Domains (1) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  4. NM_001285432.2 → NP_001272361.1  elongation factor 1-delta isoform c

    See identical proteins and their annotated locations for NP_001272361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS70638.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    A0A0R4J1L2
    Related
    ENSMUSP00000105599.3, ENSMUST00000109972.9
    Conserved Domains (1) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  5. NM_001285433.2 → NP_001272362.1  elongation factor 1-delta isoform c

    See identical proteins and their annotated locations for NP_001272362.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS70638.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    A0A0R4J1L2
    Related
    ENSMUSP00000112141.3, ENSMUST00000116440.9
    Conserved Domains (1) summary
    pfam00736
    Location:174 → 257
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  6. NM_001285434.2 → NP_001272363.1  elongation factor 1-delta isoform d

    See identical proteins and their annotated locations for NP_001272363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (d) is shorter, compared to isoform a.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS70639.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    Q91VK2
    Related
    ENSMUSP00000087109.4, ENSMUST00000089680.10
    Conserved Domains (1) summary
    pfam00736
    Location:193 → 276
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  7. NM_001411966.1 → NP_001398895.1  elongation factor 1-delta isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AC116520

  8. NM_001411967.1 → NP_001398896.1  elongation factor 1-delta isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AC116520

  9. NM_001411968.1 → NP_001398897.1  elongation factor 1-delta isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks portions of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AC116520

  10. NM_001411969.1 → NP_001398898.1  elongation factor 1-delta isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, lacks portions of the 5' and central coding regions, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) is shorter, compared to isoform a. Variants 5, 6, 7 and 12 encode the same isoform.
    Source sequence(s)
    AC116520
    UniProtKB/TrEMBL
    A0A0R4J1L2

  11. NM_001411970.1 → NP_001398899.1  elongation factor 1-delta isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
    Source sequence(s)
    AC116520
    UniProtKB/TrEMBL
    Q80T06

  12. NM_023240.4 → NP_075729.2  elongation factor 1-delta isoform b

    See identical proteins and their annotated locations for NP_075729.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2, 3, 4 and 13 encode the same isoform.
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27554.1
    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    UniProtKB/TrEMBL
    Q80T06
    Related
    ENSMUSP00000116360.2, ENSMUST00000154584.9
    Conserved Domains (1) summary
    pfam00736
    Location:198 → 281
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  13. NM_029663.3 → NP_083939.1  elongation factor 1-delta isoform a

    See identical proteins and their annotated locations for NP_083939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC116520
    Consensus CDS
    CCDS27553.1
    UniProtKB/TrEMBL
    A0A0R4J1E2, F6ZFU0
    Related
    ENSMUSP00000087110.6, ENSMUST00000089681.12
    Conserved Domains (1) summary
    pfam00736
    Location:577 → 660
    EF1_GNE; EF-1 guanine nucleotide exchange domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75766643..75781425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521267.4 → XP_006521330.1  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_006521330.1

    UniProtKB/TrEMBL
    F6ZFU0
    Conserved Domains (2) summary
    pfam16471
    Location:478 → 515
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam00736
    Location:596 → 679
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  2. XM_036159544.1 → XP_036015437.1  elongation factor 1-delta isoform X5

    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    Conserved Domains (1) summary
    pfam00736
    Location:217 → 300
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  3. XM_006521262.5 → XP_006521325.2  elongation factor 1-delta isoform X2

    UniProtKB/TrEMBL
    F6ZFU0
    Conserved Domains (2) summary
    pfam16471
    Location:477 → 514
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam00736
    Location:595 → 678
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  4. XM_006521265.5 → XP_006521328.2  elongation factor 1-delta isoform X4

    UniProtKB/TrEMBL
    F6ZFU0
    Related
    ENSMUSP00000114753.2, ENSMUST00000137426.8
    Conserved Domains (2) summary
    pfam16471
    Location:435 → 472
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam00736
    Location:553 → 636
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  5. XM_006521261.4 → XP_006521324.2  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_006521324.2

    UniProtKB/TrEMBL
    F6ZFU0
    Conserved Domains (2) summary
    pfam16471
    Location:478 → 515
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam00736
    Location:596 → 679
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  6. XM_006521264.5 → XP_006521327.2  elongation factor 1-delta isoform X3

    UniProtKB/TrEMBL
    F6ZFU0
    Conserved Domains (2) summary
    pfam16471
    Location:458 → 495
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam00736
    Location:576 → 659
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  7. XM_036159543.1 → XP_036015436.1  elongation factor 1-delta isoform X5

    UniProtKB/Swiss-Prot
    P57776, Q68FG5, Q9CWW2, Q9CWY1, Q9CYD4, Q9CYJ5
    Conserved Domains (1) summary
    pfam00736
    Location:217 → 300
    EF1_GNE; EF-1 guanine nucleotide exchange domain

  8. XM_006521266.5 → XP_006521329.2  elongation factor 1-delta isoform X1

    See identical proteins and their annotated locations for XP_006521329.2

    UniProtKB/TrEMBL
    F6ZFU0
    Conserved Domains (2) summary
    pfam16471
    Location:478 → 515
    JIP_LZII; JNK-interacting protein leucine zipper II
    pfam00736
    Location:596 → 679
    EF1_GNE; EF-1 guanine nucleotide exchange domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57776.3 GenPept UniProtKB/Swiss-Prot:P57776

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