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Lix1 limb and CNS expressed 1 [ Mus musculus (house mouse) ]

Gene ID: 66643, updated on 2-Nov-2024

Summary

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Official Symbol
Lix1provided by MGI
Official Full Name
limb and CNS expressed 1provided by MGI
Primary source
MGI:MGI:1913893
See related
Ensembl:ENSMUSG00000047786 AllianceGenome:MGI:1913893
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5730466L18Rik
Summary
Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lateral plate mesoderm; and sensory organ. Orthologous to human LIX1 (limb and CNS expressed 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 15.1), cortex adult (RPKM 9.5) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Lix1 in Genome Data Viewer
Location:
17 A3.2; 17 9.77 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (17622948..17679649)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (17402686..17459387)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3184 Neighboring gene predicted gene, 36768 Neighboring gene STARR-positive B cell enhancer ABC_E7490 Neighboring gene RIO kinase 2 Neighboring gene STARR-seq mESC enhancer starr_41952 Neighboring gene predicted gene, 26873 Neighboring gene STARR-seq mESC enhancer starr_41957 Neighboring gene STARR-seq mESC enhancer starr_41959 Neighboring gene STARR-seq mESC enhancer starr_41960 Neighboring gene STARR-seq mESC enhancer starr_41961 Neighboring gene predicted gene, 41537 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene leucyl/cystinyl aminopeptidase Neighboring gene STARR-positive B cell enhancer ABC_E5575 Neighboring gene STARR-positive B cell enhancer ABC_E7491 Neighboring gene STARR-seq mESC enhancer starr_41962 Neighboring gene STARR-positive B cell enhancer ABC_E4194 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:17762259-17762524

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype. Wakeling EN, et al. J Hered, 2011 Sep-Oct. PMID 21846745
  2. Cloning and expression analysis of chicken Lix1, a founding member of a novel gene family. Swindell EC, et al. Mech Dev, 2001 Dec. PMID 11731258
  3. Murine Lix1, a novel marker for substantia nigra, cortical layer 5, and hindbrain structures. Moeller C, et al. Brain Res Gene Expr Patterns, 2002 Oct. PMID 12638132
  4. Cecr2 mutations causing exencephaly trigger misregulation of mesenchymal/ectodermal transcription factors. Fairbridge NA, et al. Birth Defects Res A Clin Mol Teratol, 2010 Aug. PMID 20589882
  5. Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development. Dawe CE, et al. Dev Dyn, 2011 Feb. PMID 21246654

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
    Title: Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
  2. This protein is a marker for substantia nigra, cerebral cortex and hindbrain development.
    Title: Murine Lix1, a novel marker for substantia nigra, cortical layer 5, and hindbrain structures.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in autophagosome maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein limb expression 1 homolog
Names
limb expression 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025681.2 → NP_079957.2  protein limb expression 1 homolog

    See identical proteins and their annotated locations for NP_079957.2

    Status: VALIDATED

    Source sequence(s)
    BC049574, BC052700, BC063057
    Consensus CDS
    CCDS37456.1
    UniProtKB/Swiss-Prot
    Q6P566, Q8VHY1, Q9CYH4
    UniProtKB/TrEMBL
    A0A158RFU7, Q9CSQ3
    Related
    ENSMUSP00000111239.3, ENSMUST00000115576.3
    Conserved Domains (1) summary
    pfam14954
    Location:17 → 258
    LIX1; Limb expression 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    17622948..17679649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524797.5 → XP_006524860.1  protein limb expression 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_006524860.1

    UniProtKB/TrEMBL
    Q3TSN5
    Related
    ENSMUSP00000156223.2, ENSMUST00000140134.2
    Conserved Domains (1) summary
    pfam14954
    Location:15 → 131
    LIX1; Limb expression 1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P566.1 GenPept UniProtKB/Swiss-Prot:Q6P566

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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