Lix1 limb and CNS expressed 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lix1provided by MGI
Official Full Name: limb and CNS expressed 1provided by MGI
Primary source: MGI:MGI:1913893
See related: Ensembl:ENSMUSG00000047786 AllianceGenome:MGI:1913893
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5730466L18Rik
Summary: Predicted to be involved in autophagosome maturation. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lateral plate mesoderm; and sensory organ. Orthologous to human LIX1 (limb and CNS expressed 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in frontal lobe adult (RPKM 15.1), cortex adult (RPKM 9.5) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.2; 17 9.77 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (17622948..17679649)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (17402686..17459387)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
Title: Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
This protein is a marker for substantia nigra, cerebral cortex and hindbrain development.
Title: Murine Lix1, a novel marker for substantia nigra, cortical layer 5, and hindbrain structures.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

General gene information

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Markers

Lix1 (e-PCR), detects polymorphism
- UniSTS:530691

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in autophagosome maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein limb expression 1 homolog

Names: limb expression 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.