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Zscan25 zinc finger and SCAN domain containing 25 [ Mus musculus (house mouse) ]

Gene ID: 666311, updated on 28-Oct-2024

Summary

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Official Symbol
Zscan25provided by MGI
Official Full Name
zinc finger and SCAN domain containing 25provided by MGI
Primary source
MGI:MGI:3647079
See related
Ensembl:ENSMUSG00000070420 AllianceGenome:MGI:3647079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp498; EG666311
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Orthologous to human ZSCAN25 (zinc finger and SCAN domain containing 25). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 9.9), thymus adult (RPKM 8.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Zscan25 in Genome Data Viewer
Location:
5 G2; 5 85.17 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145217261..145229050)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145280451..145292240)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4805 Neighboring gene zinc finger protein 655 Neighboring gene predicted gene 9710 Neighboring gene STARR-positive B cell enhancer ABC_E6398 Neighboring gene STARR-seq mESC enhancer starr_14828 Neighboring gene STARR-seq mESC enhancer starr_14829 Neighboring gene STARR-seq mESC enhancer starr_14831 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 57 Neighboring gene sperm motility kinase 3A pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain-containing protein 25
Names
zinc finger protein 498

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081431.2 → NP_001074900.1  zinc finger and SCAN domain-containing protein 25 isoform 1

    See identical proteins and their annotated locations for NP_001074900.1

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Consensus CDS
    CCDS39387.1
    UniProtKB/TrEMBL
    B2RX31
    Related
    ENSMUSP00000091664.4, ENSMUST00000094116.5
    Conserved Domains (4) summary
    COG5048
    Location:338 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:404 → 424
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:38 → 120
    SCAN; SCAN domain
    cl02581
    Location:230 → 258
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  2. NM_001384204.1 → NP_001371133.1  zinc finger and SCAN domain-containing protein 25 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Conserved Domains (4) summary
    COG5048
    Location:272 → 465
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338 → 358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:38 → 120
    SCAN; SCAN domain
    cl02581
    Location:164 → 192
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  3. NM_001384205.1 → NP_001371134.1  zinc finger and SCAN domain-containing protein 25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Conserved Domains (4) summary
    COG5048
    Location:123 → 288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189 → 209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:284 → 309
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:15 → 43
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. NM_001384206.1 → NP_001371135.1  zinc finger and SCAN domain-containing protein 25 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127411
    UniProtKB/TrEMBL
    B2RX31
    Conserved Domains (4) summary
    COG5048
    Location:338 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:404 → 424
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:38 → 120
    SCAN; SCAN domain
    cl02581
    Location:230 → 258
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. NM_001384207.1 → NP_001371136.1  zinc finger and SCAN domain-containing protein 25 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127411
    Conserved Domains (4) summary
    COG5048
    Location:123 → 288
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189 → 209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:284 → 309
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:15 → 43
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    145217261..145229050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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