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Crls1 cardiolipin synthase 1 [ Mus musculus (house mouse) ]

Gene ID: 66586, updated on 28-Oct-2024

Summary

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Official Symbol
Crls1provided by MGI
Official Full Name
cardiolipin synthase 1provided by MGI
Primary source
MGI:MGI:1913836
See related
Ensembl:ENSMUSG00000027357 AllianceGenome:MGI:1913836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
0610009I22Rik; 4930557M15Rik; 5730490M08Rik
Summary
Predicted to enable cardiolipin synthase (CMP-forming). Predicted to be involved in cardiolipin biosynthetic process; response to phosphatidylethanolamine; and response to thyroxine. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 57. Orthologous to human CRLS1 (cardiolipin synthase 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in testis adult (RPKM 28.2), adrenal adult (RPKM 25.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Crls1 in Genome Data Viewer
Location:
2 F2; 2 64.77 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132688557..132708706)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132846650..132866786)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene chromogranin B Neighboring gene STARR-positive B cell enhancer ABC_E4502 Neighboring gene tRNA methyltransferase 6 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132672271-132672472 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene predicted gene, 54154 Neighboring gene STARR-positive B cell enhancer ABC_E9534 Neighboring gene fermitin family member 1 Neighboring gene predicted gene 14102

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. Kasahara T, et al. FASEB J, 2020 Jan. PMID 31914590
  2. Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure. Yoo Y, et al. Exp Mol Med, 2024 Apr. PMID 38556544, Free PMC Article
  3. Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling. Cheng H, et al. Biochemistry, 2008 May 27. PMID 18454555, Free PMC Article
  4. Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation. Tu C, et al. Hepatology, 2020 Dec. PMID 32096565
  5. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Sustarsic EG, et al. Cell Metab, 2018 Jul 3. PMID 29861389, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure.
    Title: Age-dependent loss of Crls1 causes myopathy and skeletal muscle regeneration failure.
  2. Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation.
    Title: Cardiolipin Synthase 1 Ameliorates NASH Through Activating Transcription Factor 3 Transcriptional Inactivation.
  3. transgenic expression of cardiolipin synthase attenuated maladaptive cardiolipin remodeling and bioenergetic inefficiency in myocardium rendered diabetic by streptozotocin treatment.
    Title: Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.
  4. CLS mRNA levels cannot be correlated with CLS enzyme activity nor CL content in the LPS model of inflammation.
    Title: Cardiolipin synthase-1 mRNA expression does not correlate with endogenous cardiolipin synthase enzyme activity in vitro and in vivo in mammalian lipopolysaccharide models of inflammation.
  5. CL has roles in in neuronal signaling, mitochondrial bioenergetics, and apoptosis
    Title: Shotgun lipidomics reveals the temporally dependent, highly diversified cardiolipin profile in the mammalian brain: temporally coordinated postnatal diversification of cardiolipin molecular species with neuronal remodeling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cardiolipin synthase (CMP-forming) IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cardiolipin synthase (CMP-forming) ISO
Inferred from Sequence Orthology
more info
  
enables cardiolipin synthase (CMP-forming) ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cardiolipin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cardiolipin biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cardiolipin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to phosphatidylethanolamine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to phosphatidylethanolamine ISO
Inferred from Sequence Orthology
more info
  
involved_in response to thyroxine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to thyroxine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cardiolipin synthase (CMP-forming)
Names
CLS
NP_001019556.1
NP_079922.2
XP_006500075.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024385.1 → NP_001019556.1  cardiolipin synthase (CMP-forming) isoform 1

    See identical proteins and their annotated locations for NP_001019556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK018180, BC048702, BC086619
    Consensus CDS
    CCDS16779.1
    UniProtKB/Swiss-Prot
    Q80ZM8, Q9D4U1
    Related
    ENSMUSP00000028835.7, ENSMUST00000028835.13
    Conserved Domains (1) summary
    COG0558
    Location:108 → 298
    PgsA; Phosphatidylglycerophosphate synthase [Lipid transport and metabolism]

  2. NM_025646.3 → NP_079922.2  cardiolipin synthase (CMP-forming) isoform 2

    See identical proteins and their annotated locations for NP_079922.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' exon and the translation initiates from a downstream AUG codon, as compared to variant 1. The encoded isoform 2 has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AK016165, BC086619
    Consensus CDS
    CCDS38247.1
    UniProtKB/TrEMBL
    A0A0C3SFZ5, E9PYF8
    Related
    ENSMUSP00000132682.2, ENSMUST00000124836.8
    Conserved Domains (1) summary
    PLN02794
    Location:1 → 174
    PLN02794; cardiolipin synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    132688557..132708706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500012.3 → XP_006500075.1  cardiolipin synthase (CMP-forming) isoform X1

    See identical proteins and their annotated locations for XP_006500075.1

    UniProtKB/TrEMBL
    E9PYF8
    Related
    ENSMUSP00000129137.2, ENSMUST00000154160.2
    Conserved Domains (1) summary
    PLN02794
    Location:10 → 189
    PLN02794; cardiolipin synthase

RNA

  1. XR_866333.4 RNA Sequence

    Related
    ENSMUST00000124834.8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001024384.1: Suppressed sequence

    Description
    NM_001024384.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZM8.1 GenPept UniProtKB/Swiss-Prot:Q80ZM8

Gene LinkOut

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