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Zscan4b zinc finger and SCAN domain containing 4B [ Mus musculus (house mouse) ]

Gene ID: 665780, updated on 2-Nov-2024

Summary

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Official Symbol
Zscan4bprovided by MGI
Official Full Name
zinc finger and SCAN domain containing 4Bprovided by MGI
Primary source
MGI:MGI:3645447
See related
Ensembl:ENSMUSG00000095339 AllianceGenome:MGI:3645447
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EG665780
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within embryo implantation. Is expressed in 1-cell stage embryo and 2-cell stage embryo. Orthologous to human ZSCAN4 (zinc finger and SCAN domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Zscan4b in Genome Data Viewer
Location:
7 A1; 7 6.71 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (10634667..10638977, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (10900740..10905050, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18019 Neighboring gene predicted gene 7836 Neighboring gene Ewing sarcoma breakpoint region 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18020 Neighboring gene STARR-seq mESC enhancer starr_18021 Neighboring gene STARR-seq mESC enhancer starr_18022 Neighboring gene STARR-seq mESC enhancer starr_18023 Neighboring gene microRNA 297-1 Neighboring gene predicted gene 7786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs. Eckersley-Maslin MA, et al. Cell Rep, 2016 Sep 27. PMID 27681430, Free PMC Article
  2. Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Falco G, et al. Dev Biol, 2007 Jul 15. PMID 17553482, Free PMC Article
  3. The RNA ligase RNA terminal phosphate cyclase B regulates mRNA alternative splicing and is required for mouse oocyte development and maintenance. Zhang H, et al. Development, 2022 Oct 1. PMID 36178098
  4. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
  5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo implantation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and SCAN domain containing 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185173.1 → NP_001172102.1  zinc finger and SCAN domain containing 4B

    Status: PROVISIONAL

    Source sequence(s)
    AC149218
    Consensus CDS
    CCDS52011.1
    UniProtKB/TrEMBL
    A0A1B0GRE8, E9Q3G0
    Related
    ENSMUSP00000127301.3, ENSMUST00000168158.3
    Conserved Domains (5) summary
    sd00017
    Location:425 → 445
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:394 → 416
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:437 → 462
    zf-H2C2_2; Zinc-finger double domain
    cl01821
    Location:441 → 489
    zf-CHCC; Zinc-finger domain
    cl02605
    Location:51 → 117
    SCAN; SCAN oligomerization domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    10634667..10638977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_018965.1: Suppressed sequence

    Description
    NG_018965.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version

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