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Tceanc2 transcription elongation factor A (SII) N-terminal and central domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 66526, updated on 2-Nov-2024

Summary

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Official Symbol
Tceanc2provided by MGI
Official Full Name
transcription elongation factor A (SII) N-terminal and central domain containing 2provided by MGI
Primary source
MGI:MGI:1913776
See related
Ensembl:ENSMUSG00000028619 AllianceGenome:MGI:1913776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tdeanc2; 2210010B22Rik; 2210012G02Rik; 6330404A07Rik
Summary
Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human TCEANC2 (transcription elongation factor A N-terminal and central domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 2.4), testis adult (RPKM 2.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tceanc2 in Genome Data Viewer
Location:
4 C7; 4 50.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (106991352..107035563, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (107134162..107178366, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1035 Neighboring gene mitochondrial ribosomal protein L37 Neighboring gene cytochrome b5 reductase-like Neighboring gene CUB domain containing protein 2 Neighboring gene predicted gene 12802 Neighboring gene STARR-positive B cell enhancer ABC_E4641 Neighboring gene transmembrane protein 59 Neighboring gene low density lipoprotein receptor class A domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article
  2. Global discovery of erythroid long noncoding RNAs reveals novel regulators of red cell maturation. Alvarez-Dominguez JR, et al. Blood, 2014 Jan 23. PMID 24200680, Free PMC Article
  3. Widespread and dynamic translational control of red blood cell development. Alvarez-Dominguez JR, et al. Blood, 2017 Feb 2. PMID 27899360, Free PMC Article
  4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
  5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription elongation factor A N-terminal and central domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025617.2 → NP_079893.1  transcription elongation factor A N-terminal and central domain-containing protein 2

    See identical proteins and their annotated locations for NP_079893.1

    Status: VALIDATED

    Source sequence(s)
    AL645723
    Consensus CDS
    CCDS18431.1
    UniProtKB/Swiss-Prot
    Q8R2M0, Q9CZZ2, Q9D7X9
    UniProtKB/TrEMBL
    D3YXQ1
    Related
    ENSMUSP00000059741.4, ENSMUST00000057043.10
    Conserved Domains (1) summary
    cd00183
    Location:38 → 111
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    106991352..107035563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503274.4 → XP_006503337.1  transcription elongation factor A N-terminal and central domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006503337.1

    UniProtKB/Swiss-Prot
    Q8R2M0, Q9CZZ2, Q9D7X9
    UniProtKB/TrEMBL
    D3YXQ1
    Conserved Domains (1) summary
    cd00183
    Location:38 → 111
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2M0.2 GenPept UniProtKB/Swiss-Prot:Q8R2M0

Gene LinkOut

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