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Smim30 small integral membrane protein 30 [ Mus musculus (house mouse) ]

Gene ID: 66520, updated on 2-Nov-2024

Summary

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Official Symbol
Smim30provided by MGI
Official Full Name
small integral membrane protein 30provided by MGI
Primary source
MGI:MGI:1913770
See related
Ensembl:ENSMUSG00000052419 AllianceGenome:MGI:1913770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610001J05Rik
Summary
Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway. Predicted to be active in endoplasmic reticulum membrane and mitochondrial membrane. Is expressed in cerebral cortex ventricular layer. Orthologous to human SMIM30 (small integral membrane protein 30). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bladder adult (RPKM 22.1), limb E14.5 (RPKM 14.3) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Smim30 in Genome Data Viewer
Location:
6 A1; 6 5.8 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (13867734..13871517, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (13867735..13871518, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4812 Neighboring gene STARR-positive B cell enhancer mm9_chr6:13645143-13645444 Neighboring gene STARR-seq mESC enhancer starr_15198 Neighboring gene predicted gene, 53312 Neighboring gene STARR-seq mESC enhancer starr_15199 Neighboring gene STARR-seq mESC enhancer starr_15200 Neighboring gene STARR-seq mESC enhancer starr_15201 Neighboring gene STARR-seq mESC enhancer starr_15202 Neighboring gene STARR-seq mESC enhancer starr_15203 Neighboring gene STARR-seq mESC enhancer starr_15204 Neighboring gene RIKEN cDNA 1110019D14 gene Neighboring gene G protein-coupled receptor 85 Neighboring gene STARR-seq mESC enhancer starr_15205 Neighboring gene predicted gene, 38767

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC99440

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
small integral membrane protein 30
Names
microprotein in antiviral immunity 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001352887.1 → NP_001339816.1  small integral membrane protein 30 precursor

    Status: VALIDATED

    Source sequence(s)
    AC113309, AK152937
    Consensus CDS
    CCDS90029.1
    UniProtKB/Swiss-Prot
    F2Z3Y9, Q8CF75
    Related
    ENSMUSP00000116702.2, ENSMUST00000139231.2
    Conserved Domains (1) summary
    pfam15873
    Location:1 → 54
    DUF4730; Domain of unknown function (DUF4730)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    13867734..13871517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183258.1: Suppressed sequence

    Description
    NM_183258.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F2Z3Y9.1 GenPept UniProtKB/Swiss-Prot:F2Z3Y9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials