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Uqcc5 ubiquinol-cytochrome c reductase complex assembly factor 5 [ Mus musculus (house mouse) ]

Gene ID: 66487, updated on 2-Nov-2024

Summary

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Official Symbol
Uqcc5provided by MGI
Official Full Name
ubiquinol-cytochrome c reductase complex assembly factor 5provided by MGI
Primary source
MGI:MGI:1913737
See related
Ensembl:ENSMUSG00000058351 AllianceGenome:MGI:1913737
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Smim4; Gm41122; 2010107H07Rik
Summary
Predicted to enable mitochondrial ribosome binding activity. Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrial inner membrane. Orthologous to human UQCC5 (ubiquinol-cytochrome c reductase complex assembly factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 21.7), kidney adult (RPKM 18.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Uqcc5 in Genome Data Viewer
Location:
14; 14 B
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30810081..30850894, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (31088127..31128930, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ES cell cis-regulatory motif 1d Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene guanine nucleotide binding protein nucleolar 3 Neighboring gene polybromo 1 Neighboring gene predicted gene 5459 Neighboring gene STARR-positive B cell enhancer ABC_E934 Neighboring gene 5'-nucleotidase domain containing 2 Neighboring gene stabilin 1 Neighboring gene predicted gene, 52148

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. Liang C, et al. Cell Rep, 2022 Aug 16. PMID 35977508
  2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mitochondrial ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables mitochondrial ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex III assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
ubiquinol-cytochrome c reductase complex assembly factor 5
Names
small integral membrane protein 4
small nucleolar RNA host gene 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308091.2 → NP_001295020.1  ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 2

    See identical proteins and their annotated locations for NP_001295020.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 3' terminal exon, resulting in a distinct 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154446
    Consensus CDS
    CCDS84105.1
    UniProtKB/Swiss-Prot
    Q8BZ92, Q8C1P1, Q8C1Q6
    Related
    ENSMUSP00000050634.6, ENSMUST00000049732.11
    Conserved Domains (1) summary
    pfam15114
    Location:4 → 68
    UPF0640; uncharacterized protein family UPF0640

  2. NM_001308464.2 → NP_001295393.1  ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 1

    See identical proteins and their annotated locations for NP_001295393.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC154446
    Consensus CDS
    CCDS84104.1
    UniProtKB/Swiss-Prot
    Q8C1Q6
    Related
    ENSMUSP00000145018.2, ENSMUST00000203261.3
    Conserved Domains (1) summary
    pfam15114
    Location:4 → 50
    UPF0640; uncharacterized protein family UPF0640

  3. NM_001308466.2 → NP_001295395.1  ubiquinol-cytochrome c reductase complex assembly factor 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains two alternate internal exons, resulting in a distinct 3' coding region and a different 3' UTR, compared to variant 1. The encoded isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC154446
    Consensus CDS
    CCDS84106.1
    UniProtKB/TrEMBL
    A0A0R3P9C4
    Related
    ENSMUSP00000067418.6, ENSMUST00000064032.10
    Conserved Domains (1) summary
    pfam15114
    Location:4 → 68
    UPF0640; uncharacterized protein family UPF0640

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30810081..30850894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1Q6.2 GenPept UniProtKB/Swiss-Prot:Q8C1Q6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials