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slc6a4a solute carrier family 6 member 4a [ Danio rerio (zebrafish) ]

Gene ID: 664719, updated on 2-Nov-2024

Summary

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Official Symbol
slc6a4aprovided by ZNC
Official Full Name
solute carrier family 6 member 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060314-1
See related
Ensembl:ENSDARG00000061165 AllianceGenome:ZFIN:ZDB-GENE-060314-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Enables serotonin:sodium:chloride symporter activity. Acts upstream of or within chloride transmembrane transport; serotonin uptake; and sodium ion transmembrane transport. Predicted to be located in membrane. Predicted to be active in neuron projection; plasma membrane; and synapse. Is expressed in brain; male organism; pharynx; and spinal cord. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anxiety disorder (multiple); depressive disorder (multiple); heart disease (multiple); and substance abuse (multiple). Orthologous to human SLC6A4 (solute carrier family 6 member 4). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See slc6a4a in Genome Data Viewer
Location:
chromosome: 15
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (28607665..28618502, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (28674922..28701640, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene si:ch211-225b7.5 Neighboring gene uncharacterized LOC137487759 Neighboring gene uncharacterized LOC137487760 Neighboring gene bleomycin hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterisation of the zebrafish serotonin transporter functionally links TM10 to the ligand binding site. Severinsen K, et al. J Neurochem, 2008 Jun. PMID 18266934
  2. Proposal for fluorescence-based in vitro assay using human and zebrafish monoamine transporters to detect biological activities of antidepressants in wastewater. Ihara M, et al. Sci Total Environ, 2021 May 20. PMID 33513512
  3. Movement disorders and neurochemical changes in zebrafish larvae after bath exposure to fluoxetine (PROZAC). Airhart MJ, et al. Neurotoxicol Teratol, 2007 Nov-Dec. PMID 17761399
  4. Adverse effects of serotonin depletion in developing zebrafish. Airhart MJ, et al. Neurotoxicol Teratol, 2012 Jan-Feb. PMID 21893190
  5. Molecular and functional characterization of the Gulf toadfish serotonin transporter SLC6A4. Amador MHB, et al. J Exp Biol, 2018 Apr 6. PMID 29487159

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serotonin:sodium:chloride symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within serotonin transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in serotonin uptake IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within serotonin uptake IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 6 member 4a
Names
serotonin transporter a
serta
solute carrier family 6 (neurotransmitter transporter), member 4a
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039972.1 → NP_001035061.1  solute carrier family 6 member 4a

    See identical proteins and their annotated locations for NP_001035061.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ285098
    UniProtKB/TrEMBL
    B3DK93, F6P9P8, Q1WGB5
    Related
    ENSDARP00000081336.4, ENSDART00000086902.5
    Conserved Domains (1) summary
    cl00456
    Location:91 → 628
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    28607665..28618502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_011006357.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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