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Rhox4d reproductive homeobox 4D [ Mus musculus (house mouse) ]

Gene ID: 664610, updated on 2-Nov-2024

Summary

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Official Symbol
Rhox4dprovided by MGI
Official Full Name
reproductive homeobox 4Dprovided by MGI
Primary source
MGI:MGI:3613388
See related
Ensembl:ENSMUSG00000079633 AllianceGenome:MGI:3613388
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rhox4c; Rhox4.4
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: This gene was previously named "Rhox4c" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.4" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4d. [07 Jan 2013]
Expression
Biased expression in placenta adult (RPKM 4.0), thymus adult (RPKM 0.3) and 1 other tissue See more
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Genomic context

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See Rhox4d in Genome Data Viewer
Location:
X A3.3; X 21.82 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36696038..36700829)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37514385..37519176)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 26494 Neighboring gene reproductive homeobox 3D, pseudogene Neighboring gene reproductive homeobox 2E Neighboring gene reproductive homeobox 3E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rhox homeobox gene cluster: recent duplication of three family members. MacLean JA 2nd, et al. Genesis, 2006 Mar. PMID 16496311
  2. Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Morris L, et al. Mamm Genome, 2006 Feb. PMID 16465597
  3. Rhox: a new homeobox gene cluster. Maclean JA 2nd, et al. Cell, 2005 Feb 11. PMID 15707895
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
reproductive homeobox 4D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039695.1 → NP_001034784.1  reproductive homeobox 4D

    See identical proteins and their annotated locations for NP_001034784.1

    Status: VALIDATED

    Source sequence(s)
    AJ972668
    Consensus CDS
    CCDS40935.1
    UniProtKB/TrEMBL
    B7ZWM1, Q2MDG0
    Related
    ENSMUSP00000110829.4, ENSMUST00000115175.4
    Conserved Domains (2) summary
    cd00086
    Location:129 → 187
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl21455
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36696038..36700829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318598.1 → XP_017174087.1  reproductive homeobox 4D isoform X1

    UniProtKB/TrEMBL
    B7ZWM1
    Conserved Domains (2) summary
    cd00086
    Location:129 → 186
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl38985
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006541531.4 → XP_006541594.1  reproductive homeobox 4D isoform X2

    UniProtKB/TrEMBL
    B7ZWM1
    Conserved Domains (1) summary
    cl38985
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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