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Rhox4a reproductive homeobox 4A [ Mus musculus (house mouse) ]

Gene ID: 664609, updated on 2-Nov-2024

Summary

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Official Symbol
Rhox4aprovided by MGI
Official Full Name
reproductive homeobox 4Aprovided by MGI
Primary source
MGI:MGI:3580240
See related
Ensembl:ENSMUSG00000079639 AllianceGenome:MGI:3580240
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rhox4; Rhox4.1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Note: This gene was previously named "Rhox4" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.1" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4a. [07 Jan 2013]
Expression
Biased expression in placenta adult (RPKM 3.5), thymus adult (RPKM 0.4) and 2 other tissues See more
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Genomic context

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See Rhox4a in Genome Data Viewer
Location:
X A3.3; X 21.69 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36528709..36533789)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37265067..37270136)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene reproductive homeobox 2A Neighboring gene reproductive homeobox 3A Neighboring gene reproductive homeobox 3A2 Neighboring gene reproductive homeobox 4A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development. Daggag H, et al. Biol Reprod, 2008 Sep. PMID 18562707
  2. Rhox homeobox gene cluster: recent duplication of three family members. MacLean JA 2nd, et al. Genesis, 2006 Mar. PMID 16496311
  3. Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Morris L, et al. Mamm Genome, 2006 Feb. PMID 16465597
  4. Rhox: a new homeobox gene cluster. Maclean JA 2nd, et al. Cell, 2005 Feb 11. PMID 15707895
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
reproductive homeobox 4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039688.3 → NP_001034777.1  reproductive homeobox 4A

    See identical proteins and their annotated locations for NP_001034777.1

    Status: VALIDATED

    Source sequence(s)
    AJ972665
    Consensus CDS
    CCDS40930.1
    UniProtKB/TrEMBL
    B7ZWB1, Q9D3I8
    Related
    ENSMUSP00000110848.4, ENSMUST00000115194.5
    Conserved Domains (2) summary
    cd00086
    Location:129 → 187
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl38985
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36528709..36533789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006541392.4 → XP_006541455.1  reproductive homeobox 4A isoform X1

    See identical proteins and their annotated locations for XP_006541455.1

    UniProtKB/TrEMBL
    B7ZWB1
    Conserved Domains (2) summary
    cd00086
    Location:129 → 186
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl38985
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. XM_006541393.3 → XP_006541456.1  reproductive homeobox 4A isoform X2

    See identical proteins and their annotated locations for XP_006541456.1

    UniProtKB/TrEMBL
    B7ZWB1
    Conserved Domains (1) summary
    cl38985
    Location:41 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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