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Rhox4g reproductive homeobox 4G [ Mus musculus (house mouse) ]

Gene ID: 664608, updated on 18-Sep-2024

Summary

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Official Symbol
Rhox4gprovided by MGI
Official Full Name
reproductive homeobox 4Gprovided by MGI
Primary source
MGI:MGI:3613394
See related
Ensembl:ENSMUSG00000079628 AllianceGenome:MGI:3613394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rhox4f; Rhox4.6; Rhox4.7
Summary
Predicted to enable identical protein binding activity and sequence-specific double-stranded DNA binding activity. Orthologous to human RHOXF2 (Rhox homeobox family member 2) and RHOXF2B (Rhox homeobox family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information
Note: This gene was previously named "Rhox4f" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox4.7" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox4g. [07 Jan 2013]
Expression
Restricted expression toward placenta adult (RPKM 3.8) See more
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Genomic context

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See Rhox4g in Genome Data Viewer
Location:
X A3.3; X 21.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (36828154..36832980, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (37646501..37651327, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 24493 Neighboring gene reproductive homeobox 2G Neighboring gene reproductive homeobox 3H Neighboring gene predicted gene, 24147 Neighboring gene reproductive homeobox 2H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A major X-linked locus affects kidney function in mice. Leduc MS, et al. Mol Genet Genomics, 2012 Dec. PMID 23011808, Free PMC Article
  2. Rhox homeobox gene cluster: recent duplication of three family members. MacLean JA 2nd, et al. Genesis, 2006 Mar. PMID 16496311
  3. Identification of a tandem duplicated array in the Rhox alpha locus on mouse chromosome X. Morris L, et al. Mamm Genome, 2006 Feb. PMID 16465597
  4. Rhox: a new homeobox gene cluster. Maclean JA 2nd, et al. Cell, 2005 Feb 11. PMID 15707895

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
reproductive homeobox 4G
Names
reproductive homeobox 4F

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039698.1 → NP_001034787.1  reproductive homeobox 4G

    See identical proteins and their annotated locations for NP_001034787.1

    Status: VALIDATED

    Source sequence(s)
    AJ972671
    Consensus CDS
    CCDS40940.1
    UniProtKB/TrEMBL
    B7ZWM1, Q2MDF7
    Related
    ENSMUSP00000110820.2, ENSMUST00000115166.3
    Conserved Domains (2) summary
    cd00086
    Location:129 → 187
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    cl21455
    Location:44 → 126
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    36828154..36832980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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