Arrdc4 arrestin domain containing 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arrdc4provided by MGI
Official Full Name: arrestin domain containing 4provided by MGI
Primary source: MGI:MGI:1913662
See related: Ensembl:ENSMUSG00000042659 AllianceGenome:MGI:1913662
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2410003C09Rik
Summary: Enables ubiquitin-like ligase-substrate adaptor activity. Involved in extracellular vesicle biogenesis; protein transport; and protein ubiquitination. Located in extracellular vesicle and plasma membrane. Orthologous to human ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 15.0), colon adult (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 C; 7 37.81 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (68386742..68398986, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (68736994..68749238, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes.
Title: Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes.
Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
Title: Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
An insulin-regulated arrestin domain protein controls hepatic glucagon action.
Title: An insulin-regulated arrestin domain protein controls hepatic glucagon action.
Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
Title: Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Title: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
Title: Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins
Title: Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like ligase-substrate adaptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in extracellular vesicle biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
involved_in protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in extracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arrestin domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042592.2 → NP_001036057.1 arrestin domain-containing protein 4 isoform 1

See identical proteins and their annotated locations for NP_001036057.1

Status: VALIDATED

Source sequence(s)

AK037198, AV245884, BY738896

Consensus CDS

CCDS39985.1

UniProtKB/Swiss-Prot

A0A0B4J1F4, Q8VD69

UniProtKB/TrEMBL

Q0GJK1

Related

ENSMUSP00000044578.8, ENSMUST00000048068.15

Conserved Domains (2) summary

smart01017
Location:188 → 315

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:19 → 166

Arrestin_N; Arrestin (or S-antigen), N-terminal domain
NM_025549.3 → NP_079825.2 arrestin domain-containing protein 4 isoform 2

See identical proteins and their annotated locations for NP_079825.2

Status: VALIDATED

Source sequence(s)

AK010352, AK037198, BY738896

Consensus CDS

CCDS52272.1

UniProtKB/TrEMBL

Q9D6S6

Related

ENSMUSP00000112962.2, ENSMUST00000118110.3

Conserved Domains (2) summary

smart01017
Location:188 → 292

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:23 → 166

Arrestin_N; Arrestin (or S-antigen), N-terminal domain