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Smim8 small integral membrane protein 8 [ Mus musculus (house mouse) ]

Gene ID: 66291, updated on 28-Oct-2024

Summary

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Official Symbol
Smim8provided by MGI
Official Full Name
small integral membrane protein 8provided by MGI
Primary source
MGI:MGI:1913541
See related
Ensembl:ENSMUSG00000028295 AllianceGenome:MGI:1913541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810030N24Rik; 2810406B13Rik
Summary
Predicted to be located in membrane. Is expressed in several structures, including adipose tissue; alimentary system; eye; genitourinary system; and nervous system. Orthologous to human SMIM8 (small integral membrane protein 8). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in testis adult (RPKM 15.8), bladder adult (RPKM 7.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Smim8 in Genome Data Viewer
Location:
4 A5; 4 16.86 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34768664..34778398, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34768664..34778396, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914 Neighboring gene STARR-seq mESC enhancer starr_09915 Neighboring gene predicted gene 136 Neighboring gene STARR-seq mESC enhancer starr_09916 Neighboring gene STARR-seq mESC enhancer starr_09917 Neighboring gene predicted gene, 57497 Neighboring gene zinc finger protein 292 Neighboring gene STARR-positive B cell enhancer mm9_chr4:34767165-34767465 Neighboring gene tubulin, beta 6 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/Cas9-mediated genome editing reveals 12 testis-enriched genes dispensable for male fertility in mice. Oyama Y, et al. Asian J Androl, 2022 May-Jun. PMID 34290169, Free PMC Article
  2. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1)  1 citation
  • Targeted (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
small integral membrane protein 8
Names
UPF0708 protein C6orf162 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330755.1 → NP_001317684.1  small integral membrane protein 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK005941, AK021236, BU946215, CO040081
    Consensus CDS
    CCDS38706.1
    UniProtKB/Swiss-Prot
    Q9CQQ0, Q9CY70
    Related
    ENSMUSP00000103766.2, ENSMUST00000108131.8
    Conserved Domains (1) summary
    pfam14937
    Location:16 → 96
    DUF4500; Domain of unknown function (DUF4500)

  2. NM_001330756.1 → NP_001317685.1  small integral membrane protein 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK005941, AK007660, AK021236, CO040081
    Consensus CDS
    CCDS38706.1
    UniProtKB/Swiss-Prot
    Q9CQQ0, Q9CY70
    Related
    ENSMUSP00000103769.2, ENSMUST00000108134.8
    Conserved Domains (1) summary
    pfam14937
    Location:16 → 96
    DUF4500; Domain of unknown function (DUF4500)

  3. NM_001330757.1 → NP_001317686.1  small integral membrane protein 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site and lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK007660, AK021236, CO040081
    Consensus CDS
    CCDS38706.1
    UniProtKB/Swiss-Prot
    Q9CQQ0, Q9CY70
    Related
    ENSMUSP00000029972.4, ENSMUST00000029972.4
    Conserved Domains (1) summary
    pfam14937
    Location:16 → 96
    DUF4500; Domain of unknown function (DUF4500)

  4. NM_025471.3 → NP_079747.1  small integral membrane protein 8

    See identical proteins and their annotated locations for NP_079747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AK005941, AK021236, CO040081
    Consensus CDS
    CCDS38706.1
    UniProtKB/Swiss-Prot
    Q9CQQ0, Q9CY70
    Related
    ENSMUSP00000103768.4, ENSMUST00000108133.10
    Conserved Domains (1) summary
    pfam14937
    Location:16 → 96
    DUF4500; Domain of unknown function (DUF4500)

RNA

  1. NR_138487.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL928738, CO040081
    Related
    ENSMUST00000139922.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34768664..34778398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538163.3 → XP_006538226.1  small integral membrane protein 8 isoform X1

    See identical proteins and their annotated locations for XP_006538226.1

    UniProtKB/Swiss-Prot
    Q9CQQ0, Q9CY70
    Related
    ENSMUSP00000103767.2, ENSMUST00000108132.8
    Conserved Domains (1) summary
    pfam14937
    Location:16 → 96
    DUF4500; Domain of unknown function (DUF4500)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CQQ0.1 GenPept UniProtKB/Swiss-Prot:Q9CQQ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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