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Cox16 cytochrome c oxidase assembly protein 16 [ Mus musculus (house mouse) ]

Gene ID: 66272, updated on 28-Oct-2024

Summary

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Official Symbol
Cox16provided by MGI
Official Full Name
cytochrome c oxidase assembly protein 16provided by MGI
Primary source
MGI:MGI:1913522
See related
Ensembl:ENSMUSG00000091803 AllianceGenome:MGI:1913522
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810020G14Rik; 1810055I05Rik
Summary
Predicted to be involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Is expressed in genitourinary system; genitourinary system mesenchyme; mesonephros; mesonephros mesenchyme; and metanephric mesenchyme. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 22. Orthologous to human COX16 (cytochrome c oxidase assembly factor COX16). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in CNS E14 (RPKM 5.8), CNS E11.5 (RPKM 5.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cox16 in Genome Data Viewer
Location:
12 D1; 12 37.6 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81405626..81531911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81358852..81485137, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 3 Neighboring gene predicted gene 3693 Neighboring gene STARR-seq mESC enhancer starr_32669 Neighboring gene STARR-seq mESC enhancer starr_32670 Neighboring gene predicted gene, 53730 Neighboring gene synaptojanin 2 binding protein Cox16 readthrough Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 4787 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene STARR-seq mESC enhancer starr_32672 Neighboring gene a disintegrin and metallopeptidase domain 4 Neighboring gene STARR-seq mESC enhancer starr_32673 Neighboring gene STARR-positive B cell enhancer ABC_E9388 Neighboring gene STARR-positive B cell enhancer ABC_E7157 Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Markers

Readthrough S2bpcox16

Readthrough gene: S2bpcox16, Included gene: Synj2bp

Homology

Clone Names

  • MGC118423

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial cytochrome c oxidase assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309808.1 → NP_001296737.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon and lacks a portion of the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AA881507, AC132391, AK007450, AK082374, AK087666
    Consensus CDS
    CCDS83978.1
    UniProtKB/TrEMBL
    E9Q3U7, E9Q5H8
    Related
    ENSMUSP00000127295.2, ENSMUST00000168463.8
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 68
    COX16; Cytochrome c oxidase assembly protein COX16

  2. NM_001309809.2 → NP_001296738.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 3

    See identical proteins and their annotated locations for NP_001296738.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC132391, AK087666
    Consensus CDS
    CCDS83976.1
    UniProtKB/TrEMBL
    E9Q5H8, Q497I8
    Related
    ENSMUSP00000105969.3, ENSMUST00000110340.9
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 70
    COX16; Cytochrome c oxidase assembly protein COX16

  3. NM_001309810.2 → NP_001296739.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 4

    See identical proteins and their annotated locations for NP_001296739.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains two alternate exons, including an alternate 3' terminal exon, compared to variant 1. It encodes isoform 4 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC132391, AK087666, BG078831
    Consensus CDS
    CCDS83977.1
    UniProtKB/TrEMBL
    E9Q5H8, G3UWC6
    Related
    ENSMUSP00000130935.2, ENSMUST00000166723.8
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 68
    COX16; Cytochrome c oxidase assembly protein COX16

  4. NM_025461.6 → NP_079737.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_079737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC132391, AK007450, AK082374
    Consensus CDS
    CCDS26020.1
    UniProtKB/Swiss-Prot
    Q8BNX4, Q99J15, Q9CR63
    Related
    ENSMUSP00000002757.4, ENSMUST00000002757.11
    Conserved Domains (1) summary
    pfam14138
    Location:16 → 88
    COX16; Cytochrome c oxidase assembly protein COX16

RNA

  1. NR_132134.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate first exon and uses an alternate splice site in the 3' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AC132391, AK007450, AK007870, AK082374

  2. NR_132135.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate first exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AC132391, AK007450, AK007870, AK082374

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    81405626..81531911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CR63.1 GenPept UniProtKB/Swiss-Prot:Q9CR63

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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