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lepA translation elongation factor 4 [ Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) ]

Gene ID: 66260412, updated on 6-Jun-2024

Summary

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Gene symbol
lepA
Gene description
translation elongation factor 4
Locus tag
HDEF_RS02580
Gene type
protein coding
Organism
Candidatus Hamiltonella defensa 5AT (Acyrthosiphon pisum) (strain: T5A, nat-host: Acyrthosiphon pisum)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; aphid secondary symbionts; Hamiltonella
Old locus tag
HDEF_0530
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Genomic context

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Sequence:
NC_012751.1 (526964..528763)

NC_012751.1Genomic Context describing neighboring genes Neighboring gene RseA family anti-sigma factor Neighboring gene RNA polymerase sigma factor RpoE Neighboring gene MucB/RseB C-terminal domain-containing protein Neighboring gene signal peptidase I Neighboring gene ribonuclease III Neighboring gene GTPase Era

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_012751.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. EF4 reveals the energy barrier for tRNA back-translocation in the peptidyl transferase center. Song G, et al. RNA Biol, 2016 Oct 2. PMID 27472653, Free PMC Article
  2. The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis. Liu H, et al. Proc Natl Acad Sci U S A, 2011 Sep 27. PMID 21930951, Free PMC Article
  3. Conserved GTPase LepA (Elongation Factor 4) functions in biogenesis of the 30S subunit of the 70S ribosome. Gibbs MR, et al. Proc Natl Acad Sci U S A, 2017 Jan 31. PMID 28096346, Free PMC Article
  4. Structure of the GTP Form of Elongation Factor 4 (EF4) Bound to the Ribosome. Kumar V, et al. J Biol Chem, 2016 Jun 17. PMID 27137929, Free PMC Article
  5. Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestors. Degnan PH, et al. Proc Natl Acad Sci U S A, 2009 Jun 2. PMID 19451630, Free PMC Article

GeneRIFs: Gene References Into Functions

General protein information

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Preferred Names
translation elongation factor 4
WP_015873109.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012751.1 Reference assembly

    Range
    526964..528763
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_015873109.1 translation elongation factor 4 [Candidatus Hamiltonella defensa]

    See identical proteins and their annotated locations for WP_015873109.1

    UniProtKB/Swiss-Prot
    C4K3Z1
    UniProtKB/TrEMBL
    A0A2D3TBU5
    Conserved Domains (1) summary
    PRK05433
    Location:1 → 597
    PRK05433; GTP-binding protein LepA; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C4K3Z1.1